144 0001852129 XXXXXXXX LIVE 0001061983 CYTOKINETICS, INCORPORATED 000-50633 350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080 6506243000 ANDREW CALLOS Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

24000 1881240.00 124432565 07/30/2026 NASDAQ Common 07/30/2026 Exercise of Stock Options Issuer N 24000 07/30/2026 Cash N 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 06/30/2026 15000 1287069.00 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 06/01/2026 15000 1111237.50 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 05/05/2026 11333 875474.25 10b5-1 Sales for ANDREW CALLOS

350 OYSTER POINT BOULEVARD SOUTH SAN FRANCISCO CA 94080

Common 05/01/2026 15857 1030705.00 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 07/30/2026 09/05/2025 /s/ Andrew Callos