X0202 SCHEDULE 13G/A 0001493152-26-003377 0001595855 XXXXXXXX LIVE 4 Common Stock, par value $0.0001 per share 03/31/2026 0001200375 Codexis, Inc. 192005106 200 Penobscot Drive Redwood CA 94063 Rule 13d-1(c) Opaleye Management Inc. MA 0.00 6785000.00 0.00 6785000.00 6785000.00 N 7.47 IA CO Opaleye, L.P. MA 0.00 6665000.00 0.00 6665000.00 6665000.00 N 7.33 PN Based on 90,869,349 Common Shares outstanding as of 03/05/2026 as reported by Codexis, Inc. on 03/11/2026, in its Form 10K Statement. James Silverman X1 0.00 6785000.00 0.00 6785000.00 6785000.00 N 7.47 IN Codexis, Inc. 200 Penobscot Drive, Redwood City, CA 94063 Opaleye Management Inc. Opaleye, L.P. James Silverman This statement is filed by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund") and (iii) James Silverman with respect to shares directly held by the Fund. The Adviser serves as investment adviser to the Fund. Mr. Silverman exercises control over the Adviser. The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein. One Boston Place, 26th Floor, Boston, MA 02108 Opaleye Management Inc. - Massachusetts Opaleye, L.P. - Massachusetts James Silverman - USA Y 6,785,000.00 7.47 0 6,785,000.00 0 6,785,000.00 N The Adviser also manages one or more separate managed accounts (the "Managed Accounts") that collectively hold 120,000 shares of Common Stock included in the aggregate amount reported herein. The clients of the Managed Accounts have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities held in such accounts. No individual Managed Account holds more than 5% of the outstanding Common Stock of the Issuer. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement by and among the reporting persons Opaleye Management Inc. /s/ James Silverman 05/05/2026 Opaleye, L.P. /s/ James Silverman 05/05/2026 James Silverman /s/ James Silverman 05/05/2026