<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001207790</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001645469</own:issuerCik>
      <own:issuerName>Monopar Therapeutics Inc.</own:issuerName>
      <own:secFileNumber>001-39070</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>1000 Skokie Blvd</com:street1>
        <com:street2>Suite 350</com:street2>
        <com:city>Wilmette</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60091</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>8473880349</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Arthur Klausner</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Employer</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Class A</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>MLPFS</own:name>
        <own:address>
          <com:street1>One Bryant Park 40th fl</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>5000</own:noOfUnitsSold>
      <own:aggregateMarketValue>485250</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>0</own:noOfUnitsOutstanding>
      <own:approxSaleDate>07/07/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Class A</own:securitiesClassTitle>
      <own:acquiredDate>08/13/2024</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>LP in LLC</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>5000</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/10/2026</own:paymentDate>
      <own:natureOfPayment>Trade Settlement with Transfer Agent (TA)</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:noticeSignature>
      <own:noticeDate>07/07/2026</own:noticeDate>
      <own:signature>Arthur Klausner</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
