X0609 4 2026-06-30 0 0001590560 uniQure N.V. QURE 0001985973 Abi-Saab Walid true C/O UNIQURE N.V. PAASHEUVELWEG 25A AMSTERDAM P7 1105BP NETHERLANDS 0 1 0 0 Chief Medical Officer 1 Ordinary Shares 2026-06-30 4 M 0 10000 5.59 A 178235 D Ordinary Shares 2026-06-30 4 S 0 10000 46.46 D 168235 D Ordinary Shares 2026-06-30 4 S 0 20000 46.40 D 148235 D Stock Option (Right to Buy) 5.59 2026-06-30 4 M 0 10000 0 D 2034-03-01 Ordinary Shares 10000 50500 D The transactions reported herein were effected pursuant to a sales plan adopted by the Reporting Person on September 26, 2025 and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.19 to $46.97. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in the footnote. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.24 to $46.80. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in the footnote. The Stock Option was granted on March 1, 2024 and vested 25% on the first anniversary of the date of grant, and vests 6.25% quarterly thereafter until fully vested. /s/ Christian Klemt, Attorney-in-Fact 2026-07-02