X0609 4 2026-09-16 0001628171 Revolution Medicines, Inc. RVMD 0001462808 Kelsey Stephen Michael false REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 false true false false See Remarks true Common Stock 2026-09-16 4 S false 85 195.0074 D 291791 D Common Stock 2026-09-16 4 S false 5484 199.3032 D 286307 D Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units. The transaction was executed in multiple trades at prices ranging from $195.00 to $195.03, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Includes 65,613 restricted stock units. Senior Advisor to the Chief Executive Officer /s/ Jack Anders, as Attorney-in-fact for Stephen Michael Kelsey 2026-09-18