X0609 4 2026-10-28 0 0001652935 ACTUATE THERAPEUTICS, INC. ACTU 0001318470 SCHMITT DANIEL M false C/O ACTUATE THERAPEUTICS, INC. 1751 RIVER RUN, SUITE 400 FORT WORTH TX 76107 1 1 0 0 President, CEO and Director 0 Common Stock 2026-10-28 4 P 0 140844 .355 A 442560 D Common Stock 564071 I By The Schmitt Family Irrevocable Trust, dated December 31, 2019 Common Stock 22223 I By The Andrew Schmitt Irrevocable Trust, dated December 31, 2019 Common Stock 22223 I By The Anna Schmitt Irrevocable Trust, dated December 31, 2019 Common Stock 22223 I By The Edward Schmitt Irrevocable Trust, dated December 31, 2019 Warrant to Purchase Common Stock 0.45 2026-10-28 4 P 0 70422 0 A 2026-10-28 2031-10-28 Common Stock 70422 70422 D Represents shares of common stock purchased on October 28, 2026 in connection with Issuers public offering. Represents detachable warrants acquired on October 28, 2026 in connection with Issuers public offering. For every two shares of common stock acquired in connection with the public offering, one detachable warrant was issued for no additional consideration. The warrant is immediately exercisable and expires 5 years from this issuance date. Represents shares held by The Schmitt Family Irrevocable Trust, dated December 31, 2019, of which the reporting person is trustee (the "Schmitt Family Trust"). Represents shares held by The Andrew Schmitt Irrevocable Trust, dated December 31, 2019, of which the reporting person is trustee. Represents shares held by The Anna Schmitt Irrevocable Trust, dated December 31, 2019, of which the reporting person is trustee. Represents shares held by The Edward Schmitt Irrevocable Trust, dated December 31, 2019, of which the reporting person is trustee. /s/ Paul Lytle, Attorney-in-Fact 2026-10-29