X0609 4 2026-10-23 0001727196 Scholar Rock Holding Corp SRRK 0001253170 AKKARAJU SRINIVAS false 628 MIDDLEFIELD ROAD PALO ALTO CA 94301 true false false false 0 Common Stock 2026-10-23 4 P 0 47000 41.31 A 6331029 I By Samsara BioCapital, L.P. Common Stock 2026-10-23 4 P 0 94000 41.31 A 624038 I By Samsara Opportunity Fund, L.P. Common Stock 2026-10-23 4 P 0 500 41.82 A 6331529 I By Samsara BioCapital, L.P. Common Stock 2026-10-23 4 P 0 1000 41.82 A 625038 I By Samsara Opportunity Fund, L.P. Common Stock 2026-10-26 4 P 0 48988 41.59 A 6380517 I By Samsara BioCapital, L.P. Common Stock 2026-10-26 4 P 0 97982 41.59 A 723020 I By Samsara Opportunity Fund, L.P. Common Stock 27971 D The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $40.77 to $41.75 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote. The shares held by Samsara BioCapital LP ("Samsara LP") prior to the reported transaction reflect the disposition of 83,585 shares in which the Reporting Person had no pecuniary interest. The disposition of such shares by Samsara LP did not involve a change in the Reporting Person's beneficial ownership of such shares and, accordingly, was exempt from reporting under Section 16. Securities are directly held by Samsara LP. Samsara BioCapital GP, LLC ("Samsara LLC") is the general partner of Samsara LP and may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person has voting and investment power over the securities held by Samsara LP and, accordingly, may be deemed to beneficially own the securities held by Samsara LP. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein. Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the securities held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein. The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $41.78 to $41.85 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $41.15 to $41.93 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote. /s/ Srinivas Akkaraju 2026-10-27