X0609 4 2026-11-11 0 0001757898 STERIS plc STE 0001697095 Burton Karen L true 70 SIR JOHN ROGERSON'S QUAY DUBLIN 2 L2 D02 R296 IRELAND 0 1 0 0 Sr. Vice Pres., CFO 0 Ordinary Shares 2026-11-11 4 M 0 5880 147.05 A 18836 D Ordinary Shares 2026-11-11 4 S 0 5880 255.62 D 12956 D Employee Stock Option (right to buy) 147.05 2026-11-11 4 M 0 5880 0 D 2029-05-31 Ordinary Shares 5880 0 D Price reflects a weighted average sale price for multiple transactions ranging from $255.22 to $256.18 per share, inclusive. The Reporting Person undertakes to provide, upon request by the SEC Staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. As of November 12, 2026, 8,499 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 1,775 on June 2, 2027; 651 on June 3, 2027; 306 on June 4, 2027; 783 on October 1, 2027; 1,775 on June 2, 2028; 651 on June 5, 2028; 783 on October 1, 2028 and 1,775 on June 4, 2029. This option to purchase 5,880 STERIS plc ordinary shares, which is fully vested, was received in connection with the redomiciliation of STERIS plc to Ireland in March 2019 in exchange for an option to purchase 5,880 ordinary shares for $147.05 per share in STERIS plc prior to the redomiciliation ("Old STERIS"), subject to the same terms and conditions as the original Old STERIS stock option. /s/ John P. Ubbing, Authorized Representative under Power of Attorney 2026-11-12