X0202 SCHEDULE 13G/A 0000919574-25-005781 0002039349 XXXXXXXX LIVE 2 Common Stock, par value $0.001 per share 10/01/2026 0001782223 Pyxis Oncology, Inc. 747324101 321 HARRISON AVENUE BOSTON MA 02118 Rule 13d-1(c) GordonMD Global Investments LP b DE 0.00 27988714.00 0.00 27988714.00 27988714.00 N 17.5 IA PN Includes 12,446,805 shares of Common Stock issuable upon exercise of warrants (the "Warrants"). As more fully described in Item 4, certain of the Warrants are subject to a 17.50% Blocker (the "17.50% Blocker"), and the percentage set forth in row (11) gives effect to such 17.50% Blocker. However, as more fully described in Item 4, the shares of Common Stock reported as being issuable upon exercise of Warrants in rows (6), (8) and (9) include the number of shares of Common Stock that would be issuable upon full exercise of the Warrants and does not give effect to such 17.50% Blocker. Therefore, the actual number of shares of Common Stock beneficially owned by such Reporting Person, after giving effect to such 17.50% Blocker, is less than the number of shares of Common Stock reported in rows (6), (8) and (9) to be issuable upon exercise of such Warrants. GordonMD Long Biased Master Fund LP b E9 0.00 27988714.00 0.00 27988714.00 27988714.00 N 17.5 PN Includes 12,446,805 shares of Common Stock issuable upon exercise of Warrants. As more fully described in Item 4, certain of the Warrants are subject to the 17.50% Blocker, and the percentage set forth in row (11) gives effect to such 17.50% Blocker. However, as more fully described in Item 4, the shares of Common Stock reported as being issuable upon exercise of Warrants in rows (6), (8) and (9) include the number of shares of Common Stock that would be issuable upon full exercise of the Warrants and does not give effect to such 17.50% Blocker. Therefore, the actual number of shares of Common Stock beneficially owned by such Reporting Person, after giving effect to such 17.50% Blocker, is less than the number of shares of Common Stock reported in rows (6), (8) and (9) to be issuable upon exercise of such Warrants. GordonMD Long Biased GP LLC b DE 0.00 27988714.00 0.00 27988714.00 27988714.00 N 17.5 OO Includes 12,446,805 shares of Common Stock issuable upon exercise of Warrants. As more fully described in Item 4, certain of the Warrants are subject to the 17.50% Blocker, and the percentage set forth in row (11) gives effect to such 17.50% Blocker. However, as more fully described in Item 4, the shares of Common Stock reported as being issuable upon exercise of Warrants in rows (6), (8) and (9) include the number of shares of Common Stock that would be issuable upon full exercise of the Warrants and does not give effect to such 17.50% Blocker. Therefore, the actual number of shares of Common Stock beneficially owned by such Reporting Person, after giving effect to such 17.50% Blocker, is less than the number of shares of Common Stock reported in rows (6), (8) and (9) to be issuable upon exercise of such Warrants. Craig D. Gordon b X1 0.00 27988714.00 0.00 27988714.00 27988714.00 N 17.5 HC IN Includes 12,446,805 shares of Common Stock issuable upon exercise of Warrants. As more fully described in Item 4, certain of the Warrants are subject to the 17.50% Blocker, and the percentage set forth in row (11) gives effect to such 17.50% Blocker. However, as more fully described in Item 4, the shares of Common Stock reported as being issuable upon exercise of Warrants in rows (6), (8) and (9) include the number of shares of Common Stock that would be issuable upon full exercise of the Warrants and does not give effect to such 17.50% Blocker. Therefore, the actual number of shares of Common Stock beneficially owned by such Reporting Person, after giving effect to such 17.50% Blocker, is less than the number of shares of Common Stock reported in rows (6), (8) and (9) to be issuable upon exercise of such Warrants. Pyxis Oncology, Inc. 321 HARRISON AVENUE, BOSTON, MA, 02118 GordonMD Global Investments LP GordonMD Long Biased Master Fund LP GordonMD Long Biased GP LLC Craig D. Gordon GordonMD Global Investments LP 9460 WILSHIRE BLVD, SUITE 420, BEVERLY HILLS, CA, 90212 GordonMD Long Biased Master Fund LP 9460 WILSHIRE BLVD, SUITE 420, BEVERLY HILLS, CA, 90212 GordonMD Long Biased GP LLC 9460 WILSHIRE BLVD, SUITE 420, BEVERLY HILLS, CA, 90212 Craig D. Gordon 9460 WILSHIRE BLVD, SUITE 420, BEVERLY HILLS, CA, 90212 GordonMD Global Investments LP - Delaware GordonMD Long Biased Master Fund LP - Cayman Islands GordonMD Long Biased GP LLC - Delaware Craig D. Gordon - United States Y GordonMD Global Investments LP - 27,988,714 GordonMD Long Biased Master Fund LP - 27,988,714 GordonMD Long Biased GP LLC - 27,988,714 Craig D. Gordon - 27,988,714 Notwithstanding anything herein to the contrary, certain of the Warrants reflected on the cover pages and set forth in this Item 4 are subject to a 17.50% Blocker whereby they are not exercisable to the extent that following such exercise, taking into account all other shares of Common Stock beneficially owned by the Reporting Persons, the Reporting Persons would beneficially own in excess of 17.50% of the Issuer's outstanding Common Stock, as calculated in a manner consistent with the provisions of Section 13(d) of the Act and the rules and regulations promulgated thereunder. Consequently, as of the date of the event which requires the filing of this statement, some of such Warrants referred to herein are not presently exercisable due to the 17.50% Blocker. GordonMD Global Investments LP - 17.5% GordonMD Long Biased Master Fund LP - 17.5% GordonMD Long Biased GP LLC - 17.5% Craig D. Gordon - 17.5% GordonMD Global Investments LP - 0 GordonMD Long Biased Master Fund LP - 0 GordonMD Long Biased GP LLC - 0 Craig D. Gordon - 0 GordonMD Global Investments LP - 27,988,714 GordonMD Long Biased Master Fund LP - 27,988,714 GordonMD Long Biased GP LLC - 27,988,714 Craig D. Gordon - 27,988,714 GordonMD Global Investments LP - 0 GordonMD Long Biased Master Fund LP - 0 GordonMD Long Biased GP LLC - 0 Craig D. Gordon - 0 GordonMD Global Investments LP - 27,988,714 GordonMD Long Biased Master Fund LP - 27,988,714 GordonMD Long Biased GP LLC - 27,988,714 Craig D. Gordon - 27,988,714 Y N All of the securities reported in this Schedule 13G are directly owned by advisory clients of GordonMD Global Investments LP. None of those advisory clients, other than GordonMD Long Biased Master Fund LP may be deemed to beneficially own more than 5% of the Common Stock, $0.001 par value. N Please see Exhibit B attached hereto. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit A - Joint Filing Agreement Exhibit B - Control Person Identification GordonMD Global Investments LP /s/ GordonMD Global Investments GP LLC 10/02/2026 GordonMD Long Biased Master Fund LP /s/ GordonMD Long Biased GP LLC 10/02/2026 GordonMD Long Biased GP LLC /s/ Craig D. Gordon 10/02/2026 Craig D. Gordon /s/ Craig D. Gordon 10/02/2026 * Each Reporting Person disclaims beneficial ownership of the reported securities except to the extent of his, her or its pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. To the extent that "ownership of 5 percent or less of a class" was indicated in Item 5, such response only applies to the Reporting Person(s) that indicated elsewhere herein that it beneficially owns five percent (5%) or less of the class.