144 0001794898 XXXXXXXX LIVE 0001636282 SPYRE THERAPEUTICS, INC. 001-37722 221 Crescent Street Building 23 Suite 105 Waltham MA 02453 6176515940 HEIDY KING-JONES Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

29335 2611695.05 88173762 10/01/2026 NASDAQ Common 10/01/2026 Exercise of Stock Options Issuer N 29335 10/01/2026 Cash N 10b5-1 Sales for HEIDY M KING-JONES

221 Crescent Street Building 23 Suite 105 Waltham MA 02453

Common 09/02/2026 400 36000.00 10b5-1 Sales for HEIDY M KING-JONES

221 Crescent Street Building 23 Suite 105 Waltham MA 02453

Common 09/01/2026 27999 2444477.89 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 10/01/2026 04/16/2026 /s/ Heidy King-Jones