X0609 4 2026-10-22 0 0001795091 OS Therapies Inc OSTX 0001433316 Francis Knuettel II false C/O OS THERAPIES INCORPORATED 115 PULLMAN CROSSING ROAD, SUITE 103 GRASONVILLE MD 21638 0 1 0 0 Chief Financial Officer 0 Common Stock 20000 I By Lara Knuettel Revocable Trust Stock options (right to buy) 1.25 2026-10-22 4 A 0 300000 0 A 2036-10-22 Common Stock 300000 300000 D The reporting person is the co-trustee of the Lara Knuettel Revocable Trust and may be deemed to beneficially own the shares of common stock held of record by such trust. The reporting person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. On October 22, 2026, the reporting person was granted options to purchase 300,000 shares of the issuer's common stock pursuant to the terms and conditions of a stock option award agreement and the issuer's amended and restated 2023 incentive compensation plan. These options vest in 12 equal installments on each monthly anniversary of the date of grant, provided that the reporting person is serving as an employee of the issuer on each applicable vesting date. /s/ Francis Knuettel II 2026-10-30