X0609 4 2026-10-01 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001723524 Sherman Darren false C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 1 0 0 See Remarks 1 Common Stock, par value $0.0001 per share ("Common Stock") 2026-10-01 4 S 0 15000 6.36 D 1119402 D Common Stock 2000 I By son The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 18, 2025. The price reported is a weighted average price. These shares were disposed in multiple transactions at prices ranging from $6.20 to $6.48. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares disposed at each separate price within the range set forth in this footnote. The reporting person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. President and Chief Operating Officer /s/ Andrew Taylor, Attorney-in-Fact 2026-10-02