X0202 SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 2 Common Stock, $0.0001 par value per share 06/30/2026 0001833214 SAB BIOTHERAPEUTICS, INC. 78397T202 777 W 41st St, Suite 401 Miami Beach FL 33140 Rule 13d-1(c) Perceptive Advisors LLC b DE 0 6627501 0 6627501 6627501 N 7.3 IA Joseph Edelman b X1 0 6627501 0 6627501 6627501 N 7.3 IN Perceptive Life Sciences Master Fund, Ltd. b E9 0 6627501 0 6627501 6627501 N 7.3 CO SAB BIOTHERAPEUTICS, INC. 777 W 41st St, Suite 401, Miami Beach, Florida 33140 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, $0.0001 par value per share (the "Common Stock") of SAB BIOTHERAPEUTICS, INC. (the "Issuer") are: Perceptive Advisors LLC ("Perceptive Advisors") Joseph Edelman ("Mr. Edelman") Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor New York, NY 10003 Perceptive Advisors is a Delaware limited liability company Mr. Edelman is a United States citizen The Master Fund is a Cayman Islands corporation Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 90,986,368 shares of Common Stock outstanding as of August 3, 2026, as reported by the Issuer in its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 6, 2026. Neither Perceptive Advisors nor Mr. Edelman directly holds any shares of Common Stock. The Master Fund directly holds 6,627,501 shares of Common Stock. Perceptive Advisors serves as the investment manager of the Master Fund and may be deemed to beneficially own the securities directly held by the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own the securities directly held by the Master Fund. Perceptive Advisors: 7.3% Mr. Edelman: 7.3% Master Fund: 7.3% Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 6,627,501 Mr. Edelman: 6,627,501 Master Fund: 6,627,501 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 6,627,501 Mr. Edelman: 6,627,501 Master Fund: 6,627,501 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 08/14/2026 Joseph Edelman /s/ Joseph Edelman 08/14/2026 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 08/14/2026