X0609 4 2026-10-01 0001842295 Maze Therapeutics, Inc. MAZE 0001676170 Coloma Jason V false C/O MAZE THERAPEUTICS, INC. 171 OYSTER POINT BOULEVARD, SUITE 300 SOUTH SAN FRANCISCO CA 94080 true true false false Chief Executive Officer 1 Common Stock 2026-10-01 4 S 0 2593 27.0241 D 15558 I The Coloma 2021 Irrevocable Trust Common Stock 2026-10-01 4 S 0 31908 27.0210 D 191447 I Coloma Family Trust Common Stock 27362 D This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.645 to $27.46 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 4 of this Form 4. These securities are directly held by The Coloma 2021 Irrevocable Trust, for which the reporting person and his spouse serve as co-trustees. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.585 to $27.47 per share, inclusive. These securities are directly held by the Coloma Family Trust, for which the reporting person and his spouse serve as co-trustees. /s/ Courtney Phillips, as attorney-in-fact 2026-10-02