144 0001861550 XXXXXXXX LIVE 0001855175 Contineum Therapeutics, Inc. 001-42001 3565 General Atomics Court, Suite 200 San Diego CA 92121 8583335280 Daniel Lorrain Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

9520 156032.80 32723877 07/01/2026 NASDAQ Common 07/01/2026 Exercise of Stock Options Issuer N 5350 07/01/2026 Cash Common 05/09/2017 Restricted Stock Units Issuer N 4170 05/09/2017 N/A N 10b5-1 Sales for DANIEL LORRAIN

3565 General Atomics Court, Suite 200 San Diego CA 92121

Common 06/30/2026 28826 462288.02 10b5-1 Sales for DANIEL LORRAIN

3565 General Atomics Court, Suite 200 San Diego CA 92121

Common 06/01/2026 4170 54862.19 10b5-1 Sales for DANIEL LORRAIN

3565 General Atomics Court, Suite 200 San Diego CA 92121

Common 05/01/2026 4170 54707.48 10b5-1 Sales for DANIEL LORRAIN

3565 General Atomics Court, Suite 200 San Diego CA 92121

Common 04/06/2026 4170 56013.94 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 07/01/2026 09/23/2025 /s/ Daniel Lorrain