X0609 4 2026-09-30 0 0001933414 Mineralys Therapeutics, Inc. MLYS 0001644975 Congleton Jon false 150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087 1 1 0 0 Chief Executive Officer 1 Common Stock 2026-09-30 4 S 0 75000 25.4622 D 528621 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on December 23, 2025. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $25.0000 to $25.8201. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Adam Levy, Attorney-in-fact 2026-10-02