X0609 4 2026-10-09 0 0001937993 Cadrenal Therapeutics, Inc. CVKD 0001275195 MURPHY JOHN RAYMOND false C/O CADRENAL THERAPEUTICS, INC. 822 A1A NORTH, SUITE 306 PONTE VEDRA FL 32082 1 0 0 0 0 Stock Option 0.91 2026-10-09 4 A 0 75000 0 A 2026-10-09 2036-10-08 Common Stock 75000 75000 D The stock options have a grant date of October 9, 2026 under the Issuer's 2022 Successor Equity Incentive Plan, were fully vested and immediately exercisable on the date of grant, and have an exercise price equal to the closing price of the Issuer's common stock on October 9, 2026. /s/ Quang X. Pham, Attorney-in-fact 2026-10-13