SCYNEXIS, Inc.

Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. Departure of Chief Financial Officer On September 9, 2026, the then-current Chief Financial Officer of SCYNEXIS, Inc. (the “Company” or “SCYNEXIS”), Ivor Macleod, CPA, MBA, notified the Company of his intent to retire. Mr. Macleod ceased serving as the Company’s Chief Financial Officer, principal financial officer and principal accounting officer effective September 9, 2026. Mr. Macleod will remain with the Company through October 9, 2026 to support a smooth transition, after which his employment with the Company will end. Appointment of New Chief Financial Officer On September 10, 2026, the Company announced that Sanjay Subramanian, MBA, has been appointed to serve as SCYNEXIS’s Chief Financial Officer, in which role he will be SCYNEXIS’s principal financial officer and principal accounting officer. Mr. Subramanian’s first date of employment was September 9, 2026. SCYNEXIS and Mr. Subramanian are parties to an employment agreement, effective as of September 9, 2026, setting forth the terms of his employment as SCYNEXIS’s Chief Financial Officer. Pursuant to the terms of the employment agreement, Mr. Subramanian will receive an annual base salary of $500,000, a one-time sign-on bonus of $20,000, a discretionary annual performance bonus of up to 40% of his base salary, and a stock option to purchase 100,000 shares of SCYNEXIS common stock at an exercise price equal to the closing price of SCYNEXIS common stock on the date of grant, vesting over four years. In addition, the employment agreement provides for severance benefits, such that in the event that SCYNEXIS terminates Mr. Subramanian’s employment agreement other than for “just cause” or Mr. Subramanian resigns for “good reason” (each as defined in the agreement), other than within 12 months after a change of control of SCYNEXIS, Mr. Subramanian will receive as severance nine months base salary, nine months accelerated vesting of equity awards, and up to nine months COBRA benefits. If such termination is within 12 months after a change of control of SCYNEXIS, Mr. Subramanian will receive as severance 18 months base salary, full accelerated vesting of equity awards, and up to 18 months COBRA benefits. Such payments are subject to reduction to avoid adverse tax results. There are no arrangements or understandings between Mr. Subramanian and any other person pursuant to which he was appointed as Chief Financial Officer. There are no family relationships between Mr. Subramanian and any director or officer of the Company, nor does Mr. Subramanian have any direct or indirect material interest in any transaction required to be disclosed pursuant to Item 404(a) of Regulation S-K. Sanjay Subramanian, age 50, is an accomplished biopharmaceutical finance executive with more than 20 years of experience in finance, capital markets, business development, and corporate strategy. Prior to joining SCYNEXIS, Mr. Subramanian served as Chief Financial Officer and Head of Business Development at Inozyme Pharma, Inc. (“Inozyme”), where he led finance, investor relations, legal, and business development activities and played a key role in Inozyme’s acquisition by BioMarin Pharmaceutical Inc.. Previously, he served as Chief Financial Officer and Head of Corporate Development at Ocugen, Inc. Earlier in his career, he held finance leadership positions at Aralez Pharmaceuticals, Bausch Health Companies, and General Motors. Mr. Subramanian earned an M.B.A. from the MIT Sloan School of Management, a Master of Science from the Massachusetts Institute of Technology, a Master of Science from The Ohio State University, and a Bachelor of Science in Mechanical Engineering from the Indian Institute of Technology Madras.

Item 8.01. Other Events. On September 10, 2026, the Company issued a press release announcing the matters described above, a copy of which is filed as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference. (d) Exhibits. Exhibit Number Description ──────────────────────────────────────────────────────────────────────────────────────────────────── 99.1 Press Release issued by SCYNEXIS, Inc. dated September 10, 2026 104 Cover Page Interactive Data File (embedded within the Inline XBRL document).