IQVIA Holdings Inc.

Item 1.01 Entry into a Material Definitive Agreement Notes Offering and Notes Indenture On September 23, 2026, IQVIA Inc. (the “Issuer”), a wholly owned subsidiary of IQVIA Holdings Inc., completed the issuance and sale of $2,000,000,000 in gross proceeds of 6.375% senior notes due 2034 (the “Notes”). The Notes were issued pursuant to an Indenture, dated September 23, 2026 (the “Indenture”), among the Issuer, U.S. Bank Trust Company, National Association, as trustee of the Notes, and certain subsidiaries of the Issuer as guarantors. The net proceeds from the Notes offering will be used to redeem in full the Issuer’s Senior 5.000% Notes due 2026, to repay a portion of the outstanding indebtedness under the Issuer’s revolving credit facility and to pay fees and expenses related to the Notes offering. The Notes are unsecured obligations of the Issuer, will mature on March 15, 2034, unless earlier repurchased or redeemed in accordance with their terms, and will bear interest at the rate of 6.375% per year, with interest payable semi-annually on March 15 and September 15 of each year, beginning on March 15, 2027. The Issuer may redeem the Notes prior to their final stated maturity, subject to a customary make-whole premium, at any time prior to September 15, 2029 (subject to a customary “equity claw” redemption right) and thereafter subject to a redemption premium declining from 3.188% to 0.000%. The foregoing description of the Notes and the Indenture is qualified in its entirety by reference to the Indenture relating thereto, a copy of which is filed as Exhibit 4.1 to this Current Report on Form 8-K.

Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant The information set forth above under Item 1.01 of this Current Report on Form 8-K is incorporated by reference into this Item 2.03.