Schrodinger, Inc.

Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. At the 2026 Annual Meeting of Stockholders of Schrödinger, Inc. (the “Company”) held on June 22, 2026 (the “Annual Meeting”), the Company’s stockholders approved an amendment (the “2026 Plan Amendment”) to the Schrödinger, Inc. 2022 Equity Incentive Plan, as amended (the “2022 Equity Incentive Plan”). The 2026 Plan Amendment, which had previously been adopted by the Company’s Board of Directors (the “Board”) subject to stockholder approval, increases the number of shares of common stock of the Company available for issuance under the 2022 Equity Incentive Plan by 3,000,000 shares. The description of the 2022 Equity Incentive Plan, as amended by the 2026 Plan Amendment, contained on pages 18 to 29 of the Company’s definitive proxy statement for the Annual Meeting, filed with the Securities and Exchange Commission (the “SEC”) on April 28, 2026 (the “Proxy Statement”), is incorporated herein by reference. A complete copy of the 2022 Equity Incentive Plan, as amended by the 2026 Plan Amendment, is attached hereto as Exhibit 99.1 and is incorporated herein by reference.

Item 5.07. Submission of Matters to a Vote of Security Holders. At the Annual Meeting, the Company’s stockholders voted on the four proposals set forth below. A more detailed description of each proposal is set forth in the Proxy Statement. Holders of the Company’s common stock were entitled to one vote per share of common stock on each matter brought before the Annual Meeting. Holders of the Company’s limited common stock were entitled to one vote per share of limited common stock on each matter brought before the Annual Meeting, except that each share of limited common stock was not entitled to vote on the election of directors. Proposal 1 - Election of Three Class III Directors The Company’s stockholders elected Richard A. Friesner, Rosana Kapeller-Libermann and Gary Sender as Class III directors of the Board, each to serve for a three-year term expiring at the 2029 Annual Meeting of Stockholders and until his or her respective successor is duly elected and qualified. The results of the stockholders’ vote with respect to the election of such Class III directors were as follows: Nominee Number of Shares of Common Stock FOR Number of Shares of Common Stock AGAINST Number of Shares of Common Stock ABSTAINING BROKER NON-VOTES ──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────── Richard A. Friesner 33,634,879 9,424,525 68,339 9,593,955 Rosana Kapeller-Libermann 32,336,273 10,723,565 67,905 9,593,955 Gary Sender 33,506,486 9,552,235 69,022 9,593,955 Proposal 2 - Advisory Vote on Executive Compensation The Company’s stockholders approved the non-binding, advisory vote on the compensation paid to its named executive officers. The results of the stockholders’ non-binding, advisory vote with respect to compensation paid to the Company’s named executive officers were as follows: Number of Shares FOR Number of Shares AGAINST Number of Shares ABSTAINING BROKER NON-VOTES ─────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────── Common Stock 42,181,182 870,926 75,635 9,593,955 Limited Common Stock 9,164,193 0 0 0 Total 51,345,375 870,926 75,635 9,593,955 Proposal 3 - Approval of an Amendment to the 2022 Equity Incentive Plan to Increase the Number of Shares of the Company’s Common Stock Available for Issuance Thereunder by 3,000,000 Shares The Company’s stockholders approved the 2026 Plan Amendment. The results of the stockholders’ vote with respect to the 2026 Plan Amendment were as follows: Number of Shares FOR Number of Shares AGAINST Number of Shares ABSTAINING BROKER NON-VOTES ─────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────── Common Stock 32,257,903 10,825,547 44,293 9,593,955 Limited Common Stock 9,164,193 0 0 0 Total 41,422,096 10,825,547 44,293 9,593,955 Proposal 4 - Ratification of the Appointment of KPMG LLP as the Company’s Independent Registered Public Accounting Firm for the Fiscal Year Ending December 31, 2026 The Company’s stockholders ratified the appointment of KPMG LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2026. The results of the stockholders’ vote with respect to such ratification were as follows: Number of Shares FOR Number of Shares AGAINST Number of Shares ABSTAINING ───────────────────────────────────────────────────────────────────────────────────────────────────────────────── Common Stock 52,509,921 179,559 32,218 Limited Common Stock 9,164,193 0 0 Total 61,674,114 179,559 32,218