Lexeo Therapeutics, Inc.

Item 1.01 Entry into a Material Definitive Agreement. On September 16, 2026, Lexeo Therapeutics, Inc. (“Lexeo” or the “Company”) entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Mantle Therapeutics Inc. (“Mantle”), Magma Merger Sub Inc., a Delaware corporation and a wholly-owned subsidiary of the Company (“Merger Sub”), and Shareholder Representative Services LLC, a Colorado limited liability company, solely in its capacity as representative, agent and attorney in fact of the Sellers. Pursuant to the Merger Agreement, Merger Sub will be merged with and into Mantle (the “Merger”), with Mantle continuing as the surviving corporation and wholly owned subsidiary of Lexeo. Capitalized terms used but not defined herein have the meanings ascribed to such terms in the Merger Agreement. Effect on Capital Stock At the effective time of the Merger (the “Effective Time”), and subject to the terms of the Merger Agreement, each outstanding share of Mantle capital stock (other than shares held by Mantle as treasury shares, shares held by Lexeo or Merger Sub, and Dissenting Shares) will be converted into the right to receive an aggregate upfront purchase price consisting of: (i) $5,300,000 in cash, subject to certain adjustments; and (ii) $3,000,000 in shares of Lexeo common stock, par value $0.0001 per share (the "Common Stock"). The Common Stock issued at the Effective Time will not be registered under the Securities Act of 1933, as amended (the "Securities Act"), or any state securities laws, and will be issued in reliance on the exemption from registration provided by Section 4(a)(2) under the Securities Act and/or Regulation D promulgated thereunder for transactions not involving a public offering. Immediately prior to the Effective Time, each outstanding share of Mantle restricted stock will vest in full and be cancelled in exchange for the right to receive the same consideration as each share of Mantle capital stock above, subject to withholding. Immediately prior to the Effective Time, each outstanding simple agreement for future equity ("SAFE") of Mantle will be cancelled in exchange for the applicable SAFE consideration, determined in accordance with the liquidity event provisions of each SAFE. Each outstanding convertible promissory note of Mantle will be cancelled upon payment of the payoff amount determined under the Merger Agreement. Contingent Consideration In addition to the consideration payable at closing, the Merger Agreement provides for the following contingent payments, none of which is guaranteed and each of which may never become payable: • Additional Cash Payment. An additional one-time aggregate cash payment of $1,000,000, payable only upon the achievement of certain events. • Milestone Payments. Up to an aggregate of $12,000,000 payable upon the achievement of specified development and regulatory milestones relating to Mantle’s product candidates, over a milestone term of 12 years. Certain of the milestone payments are payable in cash, and certain of the milestone payments are payable in shares of Common Stock valued using a thirty-day trailing volume-weighted average price based on the date of achievement such milestone. Lexeo makes no guarantees that it will achieve any milestone, and the Merger Agreement does not require Lexeo to devote any particular level of resources to the development or commercialization of Mantle’s product candidates beyond the commercially reasonable efforts standard set forth in the Merger Agreement. Conditions to the Merger The consummation of the Merger is subject to the satisfaction or waiver of customary closing conditions, including, among others: (i) receipt of the Requisite Stockholder Approval; (ii) the accuracy of each party's representations and warranties as of the closing (subject to specified materiality standards, including a material adverse effect standard for certain representations); (iii) compliance in all material respects with each party's pre-closing covenants; (iv) the absence of any legal restraint or prohibitory order; (v) the absence of a material adverse effect; and (vi) the delivery of specified ancillary agreements. Representatives, Warranties and Covenants Mantle has made customary representations, warranties and covenants in the Merger Agreement, including, among others, covenants to (i) conduct the business in the ordinary course during the period between the execution of the Merger Agreement and the consummation of the Merger, except (a) as expressly contemplated or permitted by the Merger Agreement; (b) as required by applicable law; (c) as set forth on the Company Disclosure Schedule; or (d) as Lexeo has otherwise consented to in writing (such consent not to be unreasonably withheld, delayed or conditioned), and (ii) use reasonable best efforts to take all actions necessary or advisable to consummate the Merger, and to cooperate with the other parties to the Merger Agreement in connection therewith. Lexeo and Merger Sub have also made customary representations and warranties in the Merger Agreement. Termination The Merger Agreement contains customary termination rights, including the right of either party to terminate if: (i) the Merger has not been consummated by November 16, 2026; (ii) a final, non-appealable order or law permanently prohibiting the consummation of the Merger is in effect; or (iii) the Requisite Stockholder Approval has not been obtained within one business day after execution of the Merger Agreement. Either party may also terminate upon an uncured material breach by the other party, subject to a 10 business day cure period for curable breaches. The parties may also terminate the Merger Agreement at any time prior to the Effective Time by mutual written consent. Support Agreements In connection with the execution of the Merger Agreement, on September 16, 2026, certain of Mantle’s stockholders (collectively, the “Key Stockholders”) entered into a voting and support agreement (each, a “Stockholder Support Agreement” and collectively, the “Stockholder Support Agreements”) with Lexeo and Mantle. The Key Stockholders hold, collectively, approximately 76.1% of outstanding shares of Mantle capital stock, voting together as a single class on an as-converted-to-common-stock basis, and approximately 83.5% of the outstanding shares of Mantle preferred stock. Under the Stockholder Support Agreements, the Key Stockholders have agreed to vote their shares of Mantle capital stock in favor of the adoption of the Merger Agreement and certain other matters, subject to certain terms and conditions contained therein. The foregoing description of the Merger Agreement and the transactions contemplated thereby does not purport to be complete and is qualified in its entirety by reference to the Merger Agreement, a copy of which is filed as Exhibit 2.1 hereto and is incorporated herein by reference.

Item 8.01 Other Events. On September 22, 2026, the Company issued a press release announcing its entry into the Merger Agreement as well as other strategic collaborations entered into by the Company. As part of the press release, the Company announced that it would be hosting a conference call and webcast at 8:00 a.m. ET on September 22, 2026 to discuss said transactions and provide a business update. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated by reference herein. The corporate presentation to be used in connection with the webcast described above is attached hereto as Exhibit 99.2 and is incorporated by reference herein. Also on September 22, 2026, the Company announced that it has 22 participants enrolled or imminently enrolling in its CLARITY-FA study.