Notice of Proposed Sale · 144

Insmed Incorporated

INSMNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Jul 9, 2026Accepted Jul 9, 2026, 4:29 PM EDTFiling CIK 1104506Accession 0001628280-26-047798

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Structured filing — 144

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer: INSMED INC
Issuer CIK: 0001104506
SEC file number: 000-30739
Phone: 9089779900
Person for whose account securities are to be sold: William Lewis
Relationships to issuer: Officer
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Securities proposed for sale

Securities proposed for sale · 1 reported row
Security	Proposed units	Aggregate market value	Units outstanding	Approximate sale date	Exchange	Broker / market maker
Common	10,699	1,256,029	216,752,451	07/09/2026	NASDAQ	Merrill Lynch

Broker / market maker — proposed row 1, entry 1

Name: Merrill Lynch
Street: 1800 K ST NW
Street (continued): Suite 800
City: Washington
State / country code: DC
Postal code: 20006

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
Security	Acquired	Nature of acquisition	Acquired from	Amount acquired	Gift transaction	Payment date	Nature of payment
Common	07/09/2026	Stock Plan Activity	Issuer	10,699	N	07/09/2026	n/a

Sales reported in the preceding three months

Sales reported in the preceding three months · 7 reported rows
Seller	Security	Sale date	Amount sold	Gross proceeds
William Lewis	Common	06/25/2026	21,398	2,210,653
William Lewis	Common	06/08/2026	6,515	612,576
William Lewis	Common	06/03/2026	7,605	777,746
William Lewis	Common	05/18/2026	25,564	2,718,106
William Lewis	Common	05/13/2026	13,283	1,543,186
William Lewis	Common	05/04/2026	10,699	1,469,434
William Lewis	Common	04/16/2026	10,699	1,540,292

Seller — prior-sale row 1, entry 1

Name: William Lewis
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Seller — prior-sale row 2, entry 1

Name: William Lewis
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Seller — prior-sale row 3, entry 1

Name: William Lewis
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Seller — prior-sale row 4, entry 1

Name: William Lewis
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Seller — prior-sale row 5, entry 1

Name: William Lewis
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Seller — prior-sale row 6, entry 1

Name: William Lewis
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Seller — prior-sale row 7, entry 1

Name: William Lewis
Street: 700 US Highway 202/206
City: Bridgewater
State / country code: NJ
Postal code: 08807

Prior-sale reporting

Nothing to report for the preceding three months: N

Notice signature

Notice date: 07/09/2026
Signed: William Lewis
Plan adoption dates: 09/04/2025

Company context

Insmed Incorporated is a people-first global biopharmaceutical company striving to deliver first- and best-in-class therapies to transform the lives of patients facing serious diseases. The Company is advancing a diverse portfolio of approved and mid- to late-stage investigational medicines - including two approved therapies to treat chronic, debilitating lung diseases - as well as cutting-edge drug discovery focused on serving patient communities where the need is greatest. Insmed's commercial portfolio and clinical pipeline are organized around three therapeutic areas: Respiratory, Immunology & Inflammation, and Neuro & Other Rare. The Company's research engine is advancing a wide range of technologies and modalities, including gene therapy, AI-driven protein engineering, RNA end-joining, and synthetic rescue, in the pursuit of future pipeline candidates.

Current securities

INSMNASDAQ · EQUITY · Current

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