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BCS

Beneficial Ownership Report · SCHEDULE 13G

Illumina, Inc.

ILMNNASDAQEQUITYCurrent

Beneficial Ownership Report

Filed Oct 7, 2026Accepted Oct 7, 2026, 11:47 AM EDTFiling CIK 1110803Accession 0000315066-26-002340
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Structured filing — SCHEDULE 13G

primary_doc.xml

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Subject company

Company
ILLUMINA INC
Company CIK
0001110803
Street
5200 Illumina Way
City
San Diego
State / country code
CA
Postal code
92122

Statement details

Security class
COMMON STOCK
Event date
09/30/2026
Rule designation
Rule 13d-1(b)

Reporting person 1

Name
FMR LLC
Citizenship / organization
DE
Reporting person type
HC
Aggregate amount owned
16,169,439.04
Percent of class
10.7
Sole voting power
15,355,486.88
Shared voting power
0.00
Sole dispositive power
16,169,439.04
Shared dispositive power
0.00

Reporting person 2

Name
Abigail P. Johnson
Citizenship / organization
X1
Reporting person type
IN
Aggregate amount owned
16,169,439.04
Percent of class
10.7
Sole voting power
0.00
Shared voting power
0.00
Sole dispositive power
16,169,439.04
Shared dispositive power
0.00

Item 1

Issuer

ILLUMINA INC

Principal executive office address

5200 Illumina Way,San Diego,CA,USA,92122

Item 2

Citizenship

Not applicable

Filing person

FMR LLC

Principal business or residence address

245 Summer Street, Boston, Massachusetts 02210

Item 3

Not applicable indication

N

Type of filing person

HC

Item 4

Percent of class

10.7

Amount beneficially owned

16169439.04

Sole voting power

Please see the responses to Items 5 and 6 on the cover page.

Shared voting power

0.00

Sole dispositive power

16169439.04

Shared dispositive power

0.00

Item 5

Not applicable indication

Y

Ownership of 5% or less

N

Item 6

Not applicable indication

N

Ownership on behalf of another person

One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of ILLUMINA INC. No one other person's interest in the COMMON STOCK of ILLUMINA INC is more than five percent of the total outstanding COMMON STOCK.

Item 7

Not applicable indication

N

Subsidiaries

See attached Exhibit 99.

Item 8

Not applicable indication

Y

Item 9

Not applicable indication

Y

Item 10

Not applicable indication

N

Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Exhibits

Please see Exhibit 99 for 13d-1(k) (1) agreement.

Signature comments

* This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 10, 2023, accession number: 0000315066-23-000003. ** This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 31, 2023, accession number: 0000315066-23-000038.

Signature 1

Reporting person
FMR LLC
Signed
Stephanie J. Brown
Title
Duly authorized under Power of Attorney effective as of January 3, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date
10/06/2026

Signature 2

Reporting person
Abigail P. Johnson
Signed
Stephanie J. Brown
Title
Duly authorized under Power of Attorney effective as of January 26, 2023, by and on behalf of Abigail P. Johnson**
Date
10/06/2026

Filed exhibits

Company context

Illumina is improving human health by unlocking the power of the genome. Our focus on innovation has established us as a global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical, and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture, and other emerging segments. To learn more, visit illumina.com and connect with us on X, Facebook, LinkedIn, Instagram, TikTok, and YouTube.

Current securities

Historical securities (1)

Recent company filings

  1. 10-Q filingOct 30, 2026
  2. Results of Operations and Financial ConditionOct 29, 2026
  3. Entry into a Material Definitive Agreement · Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet ArrangementOct 13, 2026
  4. 4 filingSep 9, 2026
  5. 144 filingSep 4, 2026

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