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BCS

Beneficial Ownership Report · SCHEDULE 13G

Crescent Biopharma, Inc.

CBIONASDAQEQUITYCurrent

Beneficial Ownership Report

Filed Oct 27, 2026Accepted Oct 27, 2026, 5:25 PM EDTFiling CIK 1253689Accession 0002012383-26-003736
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Structured filing — SCHEDULE 13G

primary_doc.xml

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Subject company

Company
CRESCENT BIOPHARMA INC
Company CIK
0001253689
Street
300 FIFTH AVENUE
City
Waltham
State / country code
MA
Postal code
02451

Statement details

Security class
Common Stock
Event date
09/30/2026
Rule designation
Rule 13d-1(b)

Reporting person 1

Name
BlackRock, Inc.
Citizenship / organization
DE
Reporting person type
HC
Group designation
b
Aggregate amount owned
2,075,291
Percent of class
5.6
Sole voting power
2,034,925
Shared voting power
0
Sole dispositive power
2,075,291
Shared dispositive power
0

Item 1

Issuer

CRESCENT BIOPHARMA INC

Principal executive office address

300 FIFTH AVENUE Waltham MA 02451

Item 2

Citizenship

See Item 4 of Cover Page

Filing person

BlackRock, Inc. In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units (collectively, the "Reporting Business Units") of BlackRock, Inc. and its subsidiaries and affiliates. It does not include securities, if any, beneficially owned by other business units whose beneficial ownership of securities are disaggregated from that of the Reporting Business Units in accordance with such release.

Principal business or residence address

BlackRock, Inc., 50 Hudson Yards New York, NY 10001

Item 3

Not applicable indication

N

Type of filing person

HC

Item 4

Percent of class

5.6

Amount beneficially owned

2075291

Sole voting power

2034925

Shared voting power

0

Sole dispositive power

2075291

Shared dispositive power

0

Item 5

Not applicable indication

Y

Ownership of 5% or less

N

Item 6

Not applicable indication

N

Ownership on behalf of another person

Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of the common stock of CRESCENT BIOPHARMA INC. No one person's interest in the common stock of CRESCENT BIOPHARMA INC is more than five percent of the total outstanding common shares.

Item 7

Not applicable indication

N

Subsidiaries

See Exhibit 99

Item 8

Not applicable indication

Y

Item 9

Not applicable indication

Y

Item 10

Not applicable indication

N

Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Exhibits

Exhibit 24: Power of Attorney Exhibit 99: Item 7

Signature 1

Reporting person
BlackRock, Inc.
Signed
Spencer Fleming
Title
Managing Director
Date
10/27/2026

Filed exhibits

Company context

GlycoMimetics is a late clinical-stage biotechnology company that was previously discovering and developing glycobiology-based therapies for cancers, including AML, and for inflammatory diseases. The company’s scientific approach was based on an understanding of the role that carbohydrates play in cell recognition. Its specialized chemistry platform can be used to discover small molecule drugs, known as glycomimetics, that alter carbohydrate-mediated recognition in diverse disease states, including cancers and inflammation. The company’s goal was to develop transformative therapies for diseases with high unmet medical need. Learn more at www.glycomimetics.com.

Current securities

Historical securities (1)

Recent company filings

  1. Other EventsOct 15, 2026
  2. 4 filingSep 18, 2026
  3. S-8 filingSep 18, 2026
  4. 144 filingSep 17, 2026
  5. 144 filingSep 17, 2026

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