Notice of Proposed Sale · 144

Immunome, Inc.

IMNMNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Jul 2, 2026Accepted Jul 2, 2026, 12:07 PM EDTFiling CIK 1472012Accession 0001959173-26-005049

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Structured filing — 144

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer: Immunome Inc.
Issuer CIK: 0001472012
SEC file number: 001-39580
Phone: 610-321-3700
Person for whose account securities are to be sold: Lechleider Robert
Relationships to issuer: Officer
Street: 18702 N. CREEK PARKWAY
Street (continued): SUITE 100
City: BOTHELL
State / country code: WA
Postal code: 98011

Securities proposed for sale

Securities proposed for sale · 1 reported row
Security	Proposed units	Aggregate market value	Units outstanding	Approximate sale date	Exchange	Broker / market maker
Common	55,000	1,188,000.00	113,250,394	07/02/2026	NASDAQ	Fidelity Brokerage Services LLC

Broker / market maker — proposed row 1, entry 1

Name: Fidelity Brokerage Services LLC
Street: 900 Salem Street
City: Smithfield
State / country code: RI
Postal code: 02917

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
Security	Acquired	Nature of acquisition	Acquired from	Amount acquired	Gift transaction	Payment date	Nature of payment
Common	07/02/2026	Stock Option Exercise	Issuer	55,000	N	07/02/2026	Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 1 reported row
Seller	Security	Sale date	Amount sold	Gross proceeds
Robert J. Lechleider	Common	06/25/2026	55,000	1,091,673.00

Seller — prior-sale row 1, entry 1

Name: Robert J. Lechleider
Street: 18702 N. Creek Parkway
Street (continued): Suite 100
City: Bothell
State / country code: WA
Postal code: 98011

Prior-sale reporting

Nothing to report for the preceding three months: N

Notice signature

Notice date: 07/02/2026
Signed: /s/ Gary Redman, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Robert J. Lechleider
Plan adoption dates: 03/26/2026

Company context

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

Current securities

IMNMNASDAQ · EQUITY · Current

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