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Home/The Filing Wire/Skye Bioscience, Inc./ SCHEDULE 13G

Beneficial Ownership Report · SCHEDULE 13G

Skye Bioscience, Inc.

Beneficial Ownership Report

Filed Oct 14, 2026Accepted Oct 14, 2026, 5:41 PM EDTFiling CIK 1516551Accession 0001214659-26-012924
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Structured filing — SCHEDULE 13G

primary_doc.xml

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Subject company

Company
Skye Bioscience, Inc.
Company CIK
0001516551
Street
11250 El Camino Real, Suite 100
City
San Diego
State / country code
CA
Postal code
92130

Statement details

Security class
Common Stock, par value $0.001
Event date
10/07/2026
Rule designation
Rule 13d-1(c)

Reporting person 1

Name
TANG CAPITAL MANAGEMENT, LLC
Citizenship / organization
DE
Reporting person type
OO
Aggregate amount owned
263,560.00
Percent of class
6.0
Sole voting power
0.00
Shared voting power
263,560.00
Sole dispositive power
0.00
Shared dispositive power
263,560.00
Aggregate excludes certain shares
N
Comments
Tang Capital Management, LLC ("TCM") shares voting and dispositive power over such shares with Tang Capital Partners, LP ("TCP"), Tang Capital Partners International, LP ("TCPI"), Tang Capital Partners III, Inc. ("TCP III"), Tang Capital Partners IV, Inc. ("TCP IV") and Kevin Tang. The percentages used herein are based on 4,427,676 shares of Common Stock outstanding as of August 11, 2026, as set forth in the Current Report filed on Form 8-K that was filed with the Securities and Exchange Commission on August 14, 2026.

Reporting person 2

Name
KEVIN TANG
Citizenship / organization
X1
Reporting person type
IN
Aggregate amount owned
263,560.00
Percent of class
6.0
Sole voting power
0.00
Shared voting power
263,560.00
Sole dispositive power
0.00
Shared dispositive power
263,560.00
Aggregate excludes certain shares
N
Comments
Kevin Tang shares voting and dispositive power over such shares with TCP, TCPI, TCP III, TCP IV and TCM.

Reporting person 3

Name
TANG CAPITAL PARTNERS, LP
Citizenship / organization
DE
Reporting person type
PN
Aggregate amount owned
60,000.00
Percent of class
1.4
Sole voting power
0.00
Shared voting power
60,000.00
Sole dispositive power
0.00
Shared dispositive power
60,000.00
Aggregate excludes certain shares
N
Comments
TCP shares voting and dispositive power over such shares with TCM and Kevin Tang.

Reporting person 4

Name
TANG CAPITAL PARTNERS INTERNATIONAL, LP
Citizenship / organization
DE
Reporting person type
PN
Aggregate amount owned
83,556.00
Percent of class
1.8
Sole voting power
0.00
Shared voting power
83,556.00
Sole dispositive power
0.00
Shared dispositive power
83,556.00
Aggregate excludes certain shares
N
Comments
TCPI shares voting and dispositive power over such shares with TCM and Kevin Tang.

Reporting person 5

Name
TANG CAPITAL PARTNERS III, INC
Citizenship / organization
NV
Reporting person type
CO
Aggregate amount owned
60,002.00
Percent of class
1.4
Sole voting power
0.00
Shared voting power
60,002.00
Sole dispositive power
0.00
Shared dispositive power
60,002.00
Aggregate excludes certain shares
N
Comments
TCP III shares voting and dispositive power over such shares with TCM and Kevin Tang.

Reporting person 6

Name
TANG CAPITAL PARTNERS IV, INC
Citizenship / organization
NV
Reporting person type
CO
Aggregate amount owned
60,002.00
Percent of class
1.4
Sole voting power
0.00
Shared voting power
60,002.00
Sole dispositive power
0.00
Shared dispositive power
60,002.00
Aggregate excludes certain shares
N
Comments
TCP IV shares voting and dispositive power over such shares with TCM and Kevin Tang.

Item 1

Issuer

Skye Bioscience, Inc.

Principal executive office address

11250 El Camino Real, Suite 100, San Diego, CA 92130

Item 2

Citizenship

TCM is a Delaware limited liability company. Mr. Tang is a United States citizen. TCP and TCPI are Delaware limited partnerships. TCP III and TCP IV are Nevada corporations that are indirectly wholly owned by TCP.

Filing person

This Statement on Schedule 13G (this "Statement") is filed by TCM, the general partner of TCP and TCPI; Kevin Tang, the manager of TCM and Chief Executive Officer of TCP III and TCP IV; TCP; TCPI; TCP III; and TCP IV.

Principal business or residence address

The address of TCM, Kevin Tang, TCP and TCPI is 4747 Executive Drive, Suite 210, San Diego, CA 92121. The address of TCP III and TCP IV is 400 S. 4th Street, 3rd Floor, Las Vegas, NV 89101.

Item 3

Not applicable indication

Y

Item 4

Percent of class

6.0

Amount beneficially owned

263,560

Sole voting power

0 shares

Shared voting power

263,560 shares

Sole dispositive power

0 shares

Shared dispositive power

263,560 shares

Item 5

Not applicable indication

Y

Item 6

Not applicable indication

Y

Item 7

Not applicable indication

Y

Item 8

Not applicable indication

Y

Item 9

Not applicable indication

Y

Item 10

Not applicable indication

N

Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Signature 1

Reporting person
TANG CAPITAL MANAGEMENT, LLC
Signed
/s/ Kevin Tang
Title
Manager
Date
10/14/2026

Signature 2

Reporting person
KEVIN TANG
Signed
/s/ Kevin Tang
Title
Self
Date
10/14/2026

Signature 3

Reporting person
TANG CAPITAL PARTNERS, LP
Signed
/s/ Kevin Tang
Title
Manager, Tang Capital Management, LLC, General Partner
Date
10/14/2026

Signature 4

Reporting person
TANG CAPITAL PARTNERS INTERNATIONAL, LP
Signed
/s/ Kevin Tang
Title
Manager, Tang Capital Management, LLC, General Partner
Date
10/14/2026

Signature 5

Reporting person
TANG CAPITAL PARTNERS III, INC
Signed
/s/ Kevin Tang
Title
Chief Executive Officer
Date
10/14/2026

Signature 6

Reporting person
TANG CAPITAL PARTNERS IV, INC
Signed
/s/ Kevin Tang
Title
Chief Executive Officer
Date
10/14/2026

Filed exhibits

Company context

Current securities

SKYENASDAQ · EQUITY · Current
Historical securities (9)
EMBIOTC · EQUITY · Historical · closed Jan 19, 2021LGLRDOTC · EQUITY · Historical · closed Nov 26, 2014NMUSOTC · EQUITY · Historical · closed Feb 4, 2015NMUSOTC · EQUITY · Historical · closed Mar 25, 2019NMUSEOTC · EQUITY · Historical · closed Feb 5, 2015SKYENASDAQ · EQUITY · Historical · closed Oct 19, 2026SKYEOTC · EQUITY · Historical · closed Sep 8, 2023SKYEOTC · EQUITY · Historical · closed Apr 11, 2024SKYEDOTC · EQUITY · Historical · closed Oct 11, 2023

Recent company filings

  1. PRER14A filingOct 28, 2026
  2. PREM14A filingOct 26, 2026
  3. DEFA14A filingSep 11, 2026
  4. Termination of a Material Definitive Agreement · Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements · Other EventsSep 11, 2026
  5. DEFA14A filingAug 24, 2026

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