Yarrow Bioscience, Inc.

Item 1.01 Entry into a Material Definitive Agreement. Indemnification Agreements On July 27, 2026, the Company entered into indemnification agreements (collectively, the “Indemnification Agreements”) with each of its directors and executive officers (collectively, the “Indemnitees”), which replaced and superseded any previous indemnification agreements between the Company and each such individual. The Indemnification Agreements provide for certain indemnification and advancement of expenses by the Company in connection with actions or proceedings arising out of the Indemnitees’ service as directors or officers of the Company or service to other entities at the Company’s request, on the terms and subject to the conditions set forth therein. The foregoing description of the Indemnification Agreements is not complete and is subject to and qualified in its entirety by reference to the complete text of the Indemnification Agreements, the form of which is attached hereto as Exhibit 10.4 and incorporated herein by reference.

Item 2.01 Completion of Acquisition or Disposition of Assets. The disclosure set forth in the “Introductory Note” above, including with respect to the Merger, is incorporated into this Item 2.01 by reference. All of the proposals included in the Proxy Statement/Prospectus were approved by VYNE stockholders at a special meeting of stockholders held on July 16, 2026 (the “Special Meeting”), other than the proposal to adjourn the Special Meeting, which was not presented to the stockholders. In connection with the consummation of the Merger, on the Closing Date, all of the then-outstanding (i) 4,250,000 shares of Pre-Merger Yarrow common stock, (ii) 20,242,911 shares of Pre-Merger Yarrow Series A preferred stock, (iii) 2,792,194 shares of Pre-Merger Yarrow common stock issuable upon the exercise of outstanding options, (iv) 1,096,125 shares of Pre-Merger Yarrow common stock purchased in the Pre-Closing Financing and (v) 13,068,176 Pre-Merger Yarrow pre-funded warrants purchased in the Pre-Closing Financing were converted into the right to receive shares of Company Common Stock and/or Company pre-funded warrants, as applicable, equal to the Exchange Ratio. Immediately following the application of the Exchange Ratio (which was adjusted to give effect to the Reverse Stock Split described below), and following the consummation of the transactions contemplated by the Merger Agreement, the Company had approximately 28,584,308 shares of Company Common Stock issued and outstanding (assuming the exercise in full of all Company pre-funded warrants and excluding outstanding employee and director option awards), which was comprised of: 2,803,078 shares of Company Common Stock (inclusive of issuances pursuant to the Merger Agreement and the Pre-Closing Financing); and 25,781,230 shares of Company Common Stock issuable upon the exercise of Company pre-funded warrants, each exercisable for one share of Company Common Stock at a price of $0.0001 per share. Immediately prior to the consummation of the Merger, VYNE effected the 1-for-50 Reverse Stock Split of VYNE common stock, which became legally effective on July 24, 2026. The Company Common Stock commenced trading on a post-Reverse Stock Split basis at the open of trading on July 27, 2026, and on a post-Merger basis at the open of trading on July 28, 2026.

Item 2.02 Results of Operations and Financial Condition. Pre-Merger Yarrow’s Management’s Discussion and Analysis of Financial Condition and Results of Operations as of March 31, 2026 and for the period from October 3, 2025 (inception) to March 31, 2026 is included in the Proxy Statement/Prospectus beginning on page 307 and is incorporated herein by reference.

Item 3.02 Unregistered Sales of Equity Securities. To the extent required by this Item, the information included in Item 2.01 of this Current Report on Form 8-K is incorporated herein by reference. The PIPE Securities were offered and sold in transactions exempt from registration under the Securities Act of 1933, as amended (the “Securities Act”), in reliance on Section 4(a)(2) thereof. Each of the investors represented that it was an “accredited investor,” as defined in Regulation D, and acquired the PIPE Securities for investment only and not with a view towards, or for resale in connection with, the public sale or distribution thereof. Neither this Current Report on Form 8-K nor any of the exhibits attached hereto is an offer to sell or the solicitation of an offer to buy the PIPE Securities or any other securities of the Company or Pre-Merger Yarrow.

Item 3.03 Material Modification to Rights of Security Holders. To the extent required by this Item, the information included in Item 2.01 of this Current Report on Form 8-K is incorporated herein by reference. VYNE held the Special Meeting on July 16, 2026 to present the proposals included in the Proxy Statement/Prospectus. At the Special Meeting, the VYNE stockholders approved, among other matters, amendments to the Amended and Restated Certificate of Incorporation of the Company to (i) increase the number of authorized shares of Company Common Stock from 150,000,000 shares to 300,000,000 shares (the “Authorized Share Increase”), (ii) effect the Reverse Stock Split and (iii) change its name from “VYNE Therapeutics Inc.” to “Yarrow Bioscience, Inc.” (the “Name Change”), in each case as described in the Proxy Statement/Prospectus. Following the Special Meeting, the Board approved the Reverse Stock Split at a ratio of 1-for-50. To effect the Reverse Stock Split, the Company filed a Certificate of Amendment to the Company’s Amended and Restated Certificate of Incorporation with the Secretary of State of the State of Delaware (the “Reverse Stock Split Certificate of Amendment”), with an effective time of 8:45 a.m., Eastern Daylight Time, on July 24, 2026 (“Reverse Stock Split Certificate of Amendment Effective Time”). To effect the Authorized Share Increase, the Company filed a Certificate of Amendment to the Company’s Amended and Restated Certificate of Incorporation with the Secretary of State of the State of Delaware (the “Authorized Share Increase Certificate of Amendment”), with an effective time of 12:01 a.m., Eastern Daylight Time, on July 27, 2026. To effect the Name Change, the Company filed a Certificate of Amendment to the Company’s Amended and Restated Certificate of Incorporation with the Secretary of State of the State of Delaware (the “Name Change Certificate of Amendment”), with an effective time of 12:03 a.m., Eastern Daylight Time, on July 27, 2026. As of the Reverse Stock Split Certificate of Amendment Effective Time, every 50 shares of Company Common Stock issued and outstanding immediately prior to the Reverse Stock Split were automatically and without further action on the part of the Company or any holders of such Company Common Stock, combined into one share of Company Common Stock. Immediately following the Reverse Stock Split and Merger, there were approximately 2.8 million shares of Company Common Stock issued and outstanding. No fractional shares of Company Common Stock were issued as a result of the Reverse Stock Split. Instead, any stockholder who would have otherwise been entitled to a fractional share of Company Common Stock as a result of the Reverse Stock Split (after aggregating all fractions of a share to which such stockholder would have otherwise been entitled) was, in lieu thereof, entitled to receive a cash payment equal to the product of such resulting fractional interest in one share of Company Common Stock multiplied by the closing price per share as reported by Nasdaq on July 23, 2026. The Company Common Stock commenced trading on a post-Reverse Stock Split basis on July 27, 2026, and a post-Merger basis on July 28, 2026. The Company Common Stock is represented by a new CUSIP number (92941V407). The par value per share of the Company Common Stock remains unchanged. The foregoing descriptions of the Authorized Share Increase Certificate of Amendment, Reverse Stock Split Certificate of Amendment and Name Change Certificate of Amendment do not purport to be complete and are subject to and qualified in their entirety by the full text of the Authorized Share Increase Certificate of Amendment, Reverse Stock Split Certificate of Amendment and Name Change Certificate of Amendment, copies of which are attached hereto as Exhibits 3.1, 3.2 and 3.3, respectively, and are incorporated herein by reference.

Item 5.01 Changes in Control of Registrant. To the extent required by this Item, the information included under the heading “Introductory Note” and in Item 2.01 of this Current Report on Form 8-K is incorporated herein by reference.

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers. Resignation of Directors and Certain Officers In accordance with the Merger Agreement, at the Effective Time, all of the Company’s directors resigned from the Board and any respective committee of the Board of which they were members. The resignations were not the result of any disagreements with the Company relating to the Company’s operations, policies or practices. The size of the Board was increased to six directors. In addition, each of David Domzalski, VYNE’s President and Chief Executive Officer, Iain Stuart, Ph. D., VYNE’s Chief Scientific Officer, and Mutya Harsch, VYNE’s Chief Legal Officer and General Counsel, resigned as executive officers at the Closing and their employment was terminated effective July 27, 2026, which terminations are considered to be without “cause” related to a change in control for purposes of their offer letters with VYNE. Subject to their execution and non-revocation of a release of claims, each of Mr. Domzalski, Mr. Stuart and Ms. Harsch will be eligible for the separation benefits set forth under their offer letters, as previously disclosed in the Proxy Statement/Prospectus. Stock Incentive Plan On April 23, 2026, the Board approved the Yarrow Bioscience, Inc. 2026 Stock Incentive Plan (the “2026 Stock Plan”), subject to stockholder approval and the consummation of the Merger. On July 16, 2026, the Company’s stockholders approved the 2026 Stock Plan at the Special Meeting and on July 27, 2026, the Board ratified the 2026 Stock Plan. The purpose of the 2026 Stock Plan is to promote and closely align the interests of employees, officers, non-employee directors and other individual service providers of the Company and its stockholders by providing stock-based compensation and other performance-based compensation. The initial share pool under the 2026 Stock Plan is 2,688,931. The shares that may be issued under the 2026 Stock Plan will be automatically increased on January 1 of each year beginning in 2027 and ending with a final increase on January 1, 2036, in an amount equal to 5% of the diluted stock (including Company Common Stock, preferred stock and unexercised pre-funded warrants) on the preceding December 31, unless a lower (or no) increase is determined by the administrator. Only 100,000,000 shares of Company Common Stock may be issued under the 2026 Stock Plan as incentive stock options. The foregoing description of the 2026 Stock Plan is not complete and is subject to and qualified in its entirety by reference to the complete text of the 2026 Stock Plan, a copy of which is attached hereto as Exhibit 10.5 and incorporated herein by reference. Employee Stock Purchase Plan On April 23, 2026, the Board approved the Yarrow Bioscience, Inc. 2026 Employee Stock Purchase Plan (the “2026 ESPP”), subject to stockholder approval and the consummation of the Merger. On July 16, 2026, the Company’s stockholders approved the 2026 ESPP at the Special Meeting and on July 27, 2026, the Board ratified the 2026 ESPP. The purpose of the 2026 ESPP is to provide employees of the Company and its designated subsidiaries with an opportunity to purchase shares of the Company Common Stock through accumulated contributions. The 2026 ESPP, and the rights of participants to make purchases thereunder, is intended to qualify under Section 423 of the Code. The initial share pool under the 2026 ESPP is 336,116. The shares that may be issued under the 2026 ESPP will be automatically increased on January 1 of each year beginning in 2027 and ending with a final increase on January 1, 2036 in an amount equal to the lesser of 1% of the diluted stock (including Company Common Stock, preferred stock and unexercised pre-funded warrants) on the preceding December 31 or 2,500,000, unless a lower (or no) increase is determined by the compensation committee of the Board. The foregoing description of the 2026 ESPP is not complete and is subject to and qualified in its entirety by reference to the complete text of the 2026 ESPP, a copy of which is attached hereto as Exhibit 10.6 and incorporated herein by reference. Appointment of Directors and Certain Officers On July 27, 2026, the Board appointed Rebecca Frey, Pharm. D. as the Company’s Chief Executive Officer, Tyler Zeronda as the Company's Chief Financial Officer, Steven Ryder, M.D. as the Company's Chief Medical Officer, Lori Payton, Ph. D. as the Company's Chief Development Officer and Rachael Alford, Ph. D. as the Company's Chief Operating Officer, each to serve at the discretion of the Board. On July 27, 2026, the Board set its size at six members and appointed the following six individuals to the Board: Rebecca Frey, Mona Ashiya, Steven Hoerter, Bill Lundberg, Peter Silverman and William White. In connection with his appointment to the Board, Bill Lundberg was also appointed as Chair of the Board. Rebecca Frey and Steven Hoerter are Class I directors, whose terms will expire at the Company's 2028 annual meeting of stockholders. Bill Lundberg and William White are Class II directors, whose terms will expire at the Company's 2029 annual meeting of stockholders. Mona Ashiya and Peter Silverman are Class III directors, whose terms will expire at the Company's 2027 annual meeting of stockholders. Other than as disclosed in the section of the Proxy Statement/Prospectus entitled “Certain Relationships and Related Party Transactions of the Combined Company,” beginning on page 328 and incorporated herein by reference, none of the Company's newly appointed officers or directors has a direct or indirect material interest in any transaction required to be disclosed pursuant to Item 404(a) of Regulation S-K. Pursuant to a letter agreement dated April 15, 2026, by and among OrbiMed Advisors LLC (“OrbiMed”), Pre-Merger Yarrow and, following the Closing, the Company (the “Letter Agreement”), OrbiMed is entitled to designate (i) up to two directors to the Board so long as OrbiMed holds at least 15% of the outstanding shares of the Company Common Stock or a reference ownership percentage of at least 90% of its ownership immediately following the Closing, and (ii) one such director as long as OrbiMed holds at least 7.5% of the outstanding shares or a reference ownership percentage of at least 50% (the “OrbiMed Designee(s)”), in each case as calculated pursuant to the Letter Agreement. Mona Ashiya, a Member at OrbiMed, was appointed to the Pre-Merger Yarrow board of directors in December 2025 in connection with the Pre-Merger Yarrow Series A preferred financing and serves as an OrbiMed Designee. OrbiMed has the right to designate one additional director in the future after the Closing. Other than the Merger Agreement and the Letter Agreement, there are no arrangements or understandings between the Company's officers or directors and any other person pursuant to which such officers or directors were selected as an officer or a director. There are no family relationships among any of the Company's directors and officers. Each of the newly appointed principal officers’ and directors’ biographical information is set forth below. Rebecca Frey. Ms. Frey, age 52, has served as Pre-Merger Yarrow’s Chief Executive Officer and President since October 2025 and as a member of the Pre-Merger Yarrow board of directors since December 2025. She was elected as an At-Large Director in accordance with the Pre-Merger Yarrow certificate of incorporation. Prior to joining Pre-Merger Yarrow, Ms. Frey served as a Venture Partner at RTW, a leading life sciences investment firm, from February 2025 to January 2026 and served as a Venture Partner at Elm Street Ventures from February 2021 to December 2025. Ms. Frey also served as the interim Chief Executive Officer of Prolium Bioscience, a biotechnology company, from February 2025 to July 2025. Prior to joining RTW, Ms. Frey served as Chief Executive Officer of Siduma Therapeutics, a biotechnology company, from April 2021 to May 2024, Chief Operating Officer at EvolveImmune Therapeutics, Inc., a biotechnology company, from February 2020 to December 2021, Chief Operating Officer at Cardurion Pharmaceuticals, Inc., a biotechnology company, from 2018 to 2020, and Executive Vice President of Operations at Prevail Therapeutics Inc. (formerly, Nasdaq: PRVL), a biotechnology company, from 2017 to 2018. Prior to joining Prevail, Ms. Frey held various operational leadership roles at Alexion Pharmaceuticals, Inc. (formerly, Nasdaq: ALXN), a biopharmaceutical company, from October 2006 to September 2017. Prior to her service at Alexion Pharmaceuticals, Ms. Frey worked in development and medical affairs at Novartis Pharmaceuticals and was an Assistant Professor at Northeastern University. Ms. Frey currently serves on the board of Octant Bio, a biotechnology company. Ms. Frey previously served as Executive Chair of Artelis Biopharma from August 2024 to December 2025 and served on the board of directors of Halda Therapeutics, a biopharmaceutical company, from 2019 until it was acquired by Johnson & Johnson in 2025. Ms. Frey served as a director of Latinos in Bio, a 501(c)(3) nonprofit organization, from August 2023 to February 2025. Ms. Frey holds a Doctor of Pharmacy degree from Northeastern University and completed a post-doctoral clinical research fellowship at Northeastern University and Tufts Medical Center. Ms. Frey also holds an Executive Certificate in Management and Leadership from the MIT Sloan School of Management. Ms. Frey is Directorship Certified by the National Association of Corporate Directors (NACD. DC). The Company believes Ms. Frey is qualified to serve as a member of the Board because of her extensive experience as a senior executive at numerous biotechnology companies and her operational background and expertise as an investor in life sciences companies, as well as her scientific and medical background. Tyler Zeronda. Mr. Zeronda, age 40, began serving as the Company’s Chief Financial Officer upon the Closing. Mr. Zeronda served as Chief Financial Officer and Treasurer of VYNE Therapeutics Inc. (Nasdaq: VYNE), a biopharmaceutical company, since March 2022 and previously served as VYNE’s Interim Chief Financial Officer and Treasurer from June 2021 to March 2022. Mr. Zeronda previously served as Vice President of Finance of VYNE from March 2020 to June 2021 and as Vice President of Finance of Foamix Pharmaceuticals Ltd. (formerly, Nasdaq: FOMX), a pharmaceutical company, from April 2019 until its merger with VYNE in March 2020, where he helped lead the buildout of the company’s finance department in the U.S. and was responsible for financial planning, commercial finance and supply chain. From April 2013 until April 2019, Mr. Zeronda held positions across corporate and operational finance at Aerie Pharmaceuticals Inc. (formerly, Nasdaq: AERI), a pharmaceutical company, where he helped the company scale and transition from a pre-IPO, clinical-stage company to a commercial-stage public company. Mr. Zeronda began his career at Ernst & Young, LLP where he focused on assurance services in the healthcare industry. Mr. Zeronda received his Master of Science in accounting from the University of Virginia, holds a Bachelor of Arts with a double major in economics and business and history from Lafayette College and is a licensed CPA. Steven Ryder, M.D. Dr. Ryder, age 75, has served as Pre-Merger Yarrow’s Chief Medical Officer since April 2026. Prior to joining Pre-Merger Yarrow, Dr. Ryder served as Chief Medical Officer of Rallybio Corp. (Nasdaq: RLYB), a biotechnology company, from December 2018 to March 2026, where he was responsible for leading the company’s clinical development and medical strategy. Prior to Rallybio, Dr. Ryder served as Senior Vice President, Chief Development Officer at Alexion Pharmaceuticals, Inc. (formerly, Nasdaq: ALXN), a biopharmaceutical company, from July 2013 to December 2018, where he led the global development, registration, and approval of new drug candidates for rare diseases and contributed to the overall growth of the company. Previously, he was the founding President of Astellas Pharma Global Development and spent 21 years in development at Pfizer. Dr. Ryder currently serves on the board of directors of MBX Biosciences, Inc. and Gaylord Specialty Healthcare. He received his M.D. from the Icahn School of Medicine at Mount Sinai. Lori Payton, Ph. D. Dr. Payton, age 60, has served as Pre-Merger Yarrow’s Chief Development Officer since January 2026. Prior to joining Pre-Merger Yarrow, Dr. Payton served as Principal Consultant and Chief Executive Officer at Harkness Consulting, LLC, a management consulting firm, from March 2024 to December 2025, where she was responsible for strategic planning and development consulting to several bioscience clients, and served as Senior Vice President, Development Strategy & Operations at AlloVir, Inc. (formerly, Nasdaq: ALVR), a biotechnology company, from February 2022 to January 2024, where she was responsible for Strategic Planning, Clinical Operations, Program Management, Biometrics and Vendor Management functions. In addition, Dr. Payton was a member of the executive leadership team and was accountable for achievement of critical development milestones. Dr. Payton also served as the Vice President of Strategy and Business Development at Vista Life Innovations, a nonprofit organization providing programs and services to individuals with disabilities, from July 2020 to August 2021, Senior Vice President, Corporate Strategy, Portfolio & Program Management at Sage Therapeutics (formerly, Nasdaq: SAGE) from April 2019 to June 2020 and Vice President, Global Development Team Leader at Alexion Pharmaceuticals, Inc. (formerly, Nasdaq: ALXN) from August 2014 to March 2019. Dr. Payton held several positions in Research and Development during her tenure at Pfizer from 1993 to 2013. Dr. Payton currently serves on the Long Term Planning Committee of the board of Vista Life Innovations. Dr. Payton received her B.A. in Biology from Wheaton College Massachusetts and her Ph. D. in Pharmacology & Experimental Therapeutics from Boston University School of Medicine. Rachael Alford, Ph. D. Dr. Alford, age 53, has served as Pre-Merger Yarrow’s Chief Operating Officer since January 2026. Prior to joining Pre-Merger Yarrow, Dr. Alford served as Head of Chemistry, Manufacturing and Controls at Rallybio Corporation (Nasdaq: RLYB), a biotechnology company, from May 2020 to January 2026, where she was responsible for leading the strategy, development and oversight of manufacturing processes for the company’s drug candidates. Prior to joining Rallybio, Dr. Alford held various operational and developmental roles at Alexion Pharmaceuticals, Inc. (formerly, Nasdaq: ALXN), a biopharmaceutical company, from November 2004 to May 2020, including Senior Director, Biochemical Process Development, and Vice President of Global Process Development. Dr. Alford received her B.S. in Chemistry and Ph. D. in Biophysical Chemistry from Imperial College London and was a postdoctoral research associate at Yale University. Mona Ashiya, Ph. D. Dr. Ashiya, age 57, has served as a member of the Pre-Merger Yarrow board of directors since December 2025. Dr. Ashiya is currently a General Partner at OrbiMed Advisors LLC, an investment firm, where she has served in various roles of increasing responsibility since 2010. She currently serves on the boards of directors of Shattuck Labs, Inc. (Nasdaq: STTK) and several private companies. Dr. Ashiya previously served on the boards of directors of Disc Medicine, Inc. (Nasdaq: IRON) from September 2021 to October 2025 and Sierra Oncology, Inc. (formerly, Nasdaq: SRRA) from November 2019 to July 2022. Dr. Ashiya received her B.A. from the University of California, Berkeley and her Ph. D. in Cellular, Molecular and Developmental Biology from the University of Pittsburgh. The Company believes Dr. Ashiya is qualified to serve as a member of the Board because of her experience advising and serving as a director of biotechnology companies and her expertise as an investor in life sciences companies, as well as her finance background. Steven L. Hoerter. Mr. Hoerter, age 55, has served as a member of Pre-Merger Yarrow’s board of directors since April 2026. Since July 2026, Mr. Hoerter has served as Chairman and Chief Executive Officer of MBX Biosciences, Inc. (Nasdaq: MBX), a biopharmaceutical company. Mr. Hoerter served as President and Chief Executive Officer of Deciphera Pharmaceuticals, Inc. (formerly, Nasdaq: DCPH), a biopharmaceutical company, from March 2019 to June 2024, when Deciphera was acquired by ONO Pharmaceutical. He also served as a member of the board of directors of Deciphera from May 2018 to June 2024. Prior to Deciphera, he served as Chief Commercial Officer of Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a biotechnology company, from February 2016 to March 2019. From August 2011 to March 2015, Mr. Hoerter served as Senior Vice President, Commercial at Clovis Oncology, Inc., a biotechnology company, and from March 2015 to February 2016, he served as Chief Commercial Officer. Prior to that, he held roles of increasing responsibility at F. Hoffmann-La Roche, AG, Genentech, Inc. (acquired by Roche), Chiron Corporation (acquired by Novartis AG) and Eli Lilly and Company. Mr. Hoerter has served as a member of the board of directors of ORIC Pharmaceuticals, Inc. (Nasdaq: ORIC) since August 2021, C4 Therapeutics, Inc. (Nasdaq: CCCC) since November 2024 and MBX Biosciences, Inc. (Nasdaq: MBX) since April 2025. Mr. Hoerter previously served on the board of directors of Constellation Pharmaceuticals, Inc. (formerly, Nasdaq: CNST) from September 2018 until it was acquired by MorphoSys AG in July 2021 and Ignyta, Inc. (formerly, Nasdaq: RXDX) from December 2016 until it was acquired by Roche in February 2018. Mr. Hoerter received his B.A. from Bucknell University, his M.B.A. from Tilburg University and his M.S. in management from Purdue University. The Company believes Mr. Hoerter is qualified to serve as a member of the Board because of his extensive management and commercial expertise in the biotechnology industry and his experience serving as a director of public biotechnology companies. Bill Lundberg, M.D. Dr. Lundberg, age 62, has served as Chair of Pre-Merger Yarrow’s board of directors since April 2026. Since August 2018, Dr. Lundberg has served as a Partner at Cold Spring Partners, LLC, an investment firm. Dr. Lundberg previously served as President and Chief Executive Officer of Merus N.V. (formerly, Nasdaq: MRUS), a biotechnology company, from December 2019 until Merus was acquired by Genmab A/S in December 2025, and as the Principal Financial Officer of Merus from December 2019 to June 2023. Dr. Lundberg also served as a member of the board of directors of Merus from June 2019 to December 2025. Prior to joining Merus, he served as Chief Scientific Officer of CRISPR Therapeutics AG (Nasdaq: CRSP), a biotechnology company, from January 2015 to February 2018. From February 2011 to January 2015, Dr. Lundberg served as Vice President and Head of Translational Medicine at Alexion Pharmaceuticals, Inc. (formerly, Nasdaq: ALXN), a biopharmaceutical company. Prior to that, he served as Director and Chief Medical Officer of Taligen Therapeutics, Inc., a biotechnology company acquired by Alexion in 2011. Prior to joining Taligen, Dr. Lundberg held roles of increasing responsibility in clinical drug development and medical affairs at Xanthus Pharmaceuticals, Inc. (acquired by Antisoma plc), Wyeth (acquired by Pfizer Inc.), and Genzyme Corporation (formerly, Nasdaq: GENZ). Dr. Lundberg has served as a member of the board of directors of Q32 Bio Inc. (Nasdaq: QTTB) since September 2017 and previously served on the board of directors of Vor Biopharma Inc. (Nasdaq: VOR) from July 2019 to July 2025. Dr. Lundberg received his M.D. from Stanford University and his M.B.A. from the University of Massachusetts. He completed post-doctoral training at the Whitehead Institute/MIT and clinical training in Medicine and Medical Oncology at Harvard Medical School and the Dana-Farber Cancer Institute. The Company believes Dr. Lundberg is qualified to serve as a member of the Board because of his experience advising and serving as an executive director of biotechnology companies and his expertise in medicine and clinical drug development. Peter B. Silverman, J.D. Mr. Silverman, age 48, has served as a member of Pre-Merger Yarrow’s board of directors since April 2026. Mr. Silverman previously served as Chief Operating Officer of Merus N.V. (formerly, Nasdaq: MRUS), a biotechnology company, from January 2023 until its acquisition by Genmab A/S in December 2025. Prior to serving as Chief Operating Officer, Mr. Silverman held several leadership roles at Merus, including Head of Utrecht from April 2020 to January 2023, General Counsel from February 2018 to December 2025, and Chief Intellectual Property Officer and Head of U.S. Legal from February 2017 to February 2018. Before joining Merus, Mr. Silverman was a Partner at Kirkland & Ellis LLP, an international law firm, where he represented numerous life sciences companies concerning an array of legal matters and technologies. Previously, Mr. Silverman was an associate at Kaye Scholer LLP (now Arnold & Porter Kaye Scholer LLP), and prior to that Mr. Silverman served as judicial law clerk to U.S. District Court Judge Anne E. Thompson of the District of New Jersey. He holds a J.D. from Fordham University School of Law and a B.A. in biology from the University of Rochester. The Company believes Mr. Silverman is qualified to serve as a member of the Board because of his leadership, operational and business experience in the life sciences industry. William White, J.D. Mr. White, age 53, has served as a member of Pre-Merger Yarrow’s board of directors since April 2026. Since June 2026, Mr. White has served as Chief Financial Officer & Head of Corporate Development of Avere Therapeutics, Inc., a privately-held biotechnology company. Mr. White served as the Executive Vice President, Chief Financial Officer and Head of Corporate Development and Treasurer at Akero Therapeutics, Inc. (Nasdaq: AKRO), a biotechnology company, from April 2019 until its acquisition by Novo Nordisk in December 2025. Before joining Akero, Mr. White served as a Managing Director and Head of US Life Sciences Investment Banking at Deutsche Bank AG, an investment banking company, from September 2017 until March 2019. Prior to that position, Mr. White was a Managing Director in Healthcare Investment Banking at Citigroup Inc., a multinational investment bank and financial services company, from May 2006 until September 2017. Previously, he served as an associate and later as a Vice President in Healthcare Investment Banking at Goldman, Sachs & Co., a global financial institution, from November 2000 to March 2006. Mr. White has served as a member of the board of directors of Disc Medicine, Inc. (Nasdaq: IRON) since December 2020 and previously served on the board of directors of Ventyx Biosciences, Inc. (formerly, Nasdaq: VTYX) from May 2021 until its acquisition by Eli Lilly and Company in March 2026. Mr. White received an A.B. from Princeton University, an M.P.P. from Harvard University and a J.D. from Columbia University. The Company believes Mr. White is qualified to serve as a member of the Board because of his extensive financial leadership experience in the life sciences industry and in healthcare investment banking. Board Committees Audit Committee In connection with the Closing, Mr. White (Chair), Mr. Hoerter and Dr. Lundberg were appointed to the audit committee of the Board. Compensation Committee In connection with the Closing, Mr. Hoerter (Chair), Dr. Ashiya and Mr. Silverman were appointed to the compensation committee of the Board. Governance Committee In connection with the Closing, Dr. Lundberg (Chair), Mr. White and Mr. Silverman were appointed to the nominating and corporate governance committee of the Board. Non-Employee Director Compensation Program Non-employee members of the Board are eligible to receive cash and equity compensation in accordance with our non-employee director compensation program. As of the Closing, this program provides for the following annual cash retainers: Annual Retainer Board Retainers Chair $70,000 Non-Chair Member $40,000 Audit Committee Retainers: Chair $15,000 Non-Chair Member $7,500 Compensation Committee Retainers: Chair $12,000 Non-Chair Member $6,000 Nominating Committee Retainers Chair $10,000 Non-Chair Member $5,000 In connection with the Company’s annual meeting of stockholders, each non-employee member of the Board will receive an annual grant of options to purchase Company Common Stock equal to 0.054% of the Company, which will vest on the earlier of the next annual stockholder meeting or the first anniversary of the date of grant. In addition, in connection with a non-employee director’s initial appointment to the Board, they will receive an initial grant of options to purchase Company Common Stock equal to 0.108% of the Company, in connection with a director’s appointment to the Board, subject to vesting in equal monthly installments through the third anniversary of the date of grant. Additionally, all members of the Board are reimbursed for reasonable and documented out-of-pocket travel and lodging expenses incurred in connection with attending meetings and activities of the Board and its committees. Amended and Restated Offer Letters On July 27, 2026, as approved by the Compensation Committee of the Board, the Company entered into amended and restated offer letters (the “A&R Offer Letters”) with each of Ms. Frey and Dr. Alford. Under Ms. Frey’s A&R Offer Letter, she will receive an annual base salary of $660,000 and a target annual bonus of 55% of base salary. In the event of Ms. Frey’s termination without “cause” or resignation for “good reason,” she would be eligible for the following severance benefits under the A&R Offer Letter, subject to a release of claims: (i) if such termination is more than three months prior to more than 12 months after a change in control of the Company (the “CIC Protection Period”), 12 months of base salary continuation, 12 months of subsidized benefits continuation and a pro-rated annual bonus or (ii) if such termination is during the CIC Protection Period, (a) 1.5 times the sum of her base salary and target bonus, payable in installments over 18 months, (b) 18 months of subsidized benefits continuation, (c) a pro-rated annual bonus, and (d) full acceleration of all outstanding equity awards (with any performance criteria based on the greater of target or actual performance). Additionally, in the event of Ms. Frey’s death or disability, she would receive a pro-rated annual bonus. Under Dr. Alford’s A&R Offer Letter, she will receive an annual base salary of $470,000 and a target annual bonus of 40% of base salary. In the event of Dr. Alford’s termination without “cause” or resignation for “good reason,” she would be eligible for the following severance benefits under the A&R Offer Letter, subject to a release of claims: (i) if such termination outside of the CIC Protection Period, nine months of base salary continuation and nine months of subsidized benefits continuation and a pro-rated annual bonus or (ii) if such termination is during the CIC Protection Period, (a) the sum of her base salary and target bonus, payable in installments over 12 months, (b) 12 months of subsidized benefits continuation, and (c) full acceleration of all outstanding equity awards (with any performance criteria based on the greater of target or actual performance). The foregoing description of the A&R Offer Letters does not purport to be complete and is subject to and qualified in its entirety by reference to the full text of the A&R Offer Letters, copies of which are attached hereto as Exhibits 10.7 and 10.8.

Item 5.03 Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year. Amendments to Certificate of Incorporation The information set forth in Item 3.03 of this Current Report on Form 8-K is incorporated herein by reference. Amended and Restated Bylaws In connection with the Closing, on July 27, 2026, the Board adopted the Amended and Restated Bylaws of the Company (the “Amended and Restated Bylaws”), which amended and restated the Company’s bylaws as in effect immediately prior to the Closing in their entirety. The Amended and Restated Bylaws, among other things: update various provisions regarding the order and conduct of meetings of stockholders and directors; update the voting standard for most matters presented to stockholders other than the election of directors to the Delaware default of a majority of the voting power of the shares present and entitled to vote on the matter; increase the quorum requirement for stockholder meetings from one-third to a majority of the voting power of the stock outstanding and entitled to vote at the meeting; update the procedural and disclosure requirements for director nominations and business proposals submitted by stockholders (other than proposals submitted pursuant to Rule 14a-8 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)); ────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────── opt out of General Corporation Law of the State of Delaware (the “DGCL”) Section 116 regarding electronic delivery of documents or information; clarify certain procedures and standards with respect to the rights to indemnification and advancement of expenses, including for persons serving as directors and officers of subsidiaries of the Company; designate the Delaware Court of Chancery, the federal district courts of the State of Delaware and federal district courts generally as the sole forum for certain types of disputes, as allowed by law; add new emergency bylaws provisions contemplated by Section 110 of the DGCL; update provisions to align with the Company’s governance structure and the DGCL and remove provisions otherwise duplicative with other Company documents or the DGCL; and make various other updates, including clarifying, ministerial and conforming changes. ───────────────────────────────────────────────────────────────────────────────────────── The foregoing description of the Amended and Restated Bylaws does not purport to be complete and is subject to and qualified in its entirety by reference to the full text of the Amended and Restated Bylaws, a copy of which is attached hereto as Exhibit 3.5 and is incorporated herein by reference.

Item 5.05 Amendments to the Registrant’s Code of Ethics, or Waiver of a Provision of the Code of Ethics. On July 27, 2026, in connection with the Closing, the Board adopted a new Code of Business Conduct and Ethics of the Company (the “Code of Conduct”), effective as of such date. The Code of Conduct supersedes the existing Code of Business Conduct and Ethics, as previously adopted by VYNE’s board of directors (the “Existing Code of Conduct”). The Code of Conduct applies to all directors, officers and employees of the Company and is intended to enhance understanding of the Company’s standards of ethical business practices and promote awareness of ethical issues that may be encountered in carrying out a director’s, officer’s or employee’s responsibilities. Among other things, the Code of Conduct: establishes the Company’s policies and standards with respect to (i) conflicts of interest, gifts and corporate opportunities, (ii) fair dealing, confidential information, privacy and use of Company assets and systems, (iii) legal and regulatory compliance, insider trading and anti-corruption standards, including pursuant to the Foreign Corrupt Practices Act, (iv) the Company’s disclosure obligations and recordkeeping procedures and (v) anti-discrimination, equal employment opportunity and health and safety; establishes the Company’s whistleblower hotline and procedures for reporting potential violations; and establishes the Company’s policies and procedures with respect to an amendment or waiver of the Code of Conduct. The adoption of the Code of Conduct did not result in any explicit or implicit waiver of any provision of the Existing Code of Conduct. The foregoing description of the Code of Conduct does not purport to be complete and is subject to and qualified in its entirety by reference to the full text of the Code of Conduct, a copy of which is attached hereto as Exhibit 14.1 and is incorporated herein by reference.

Item 7.01 Regulation FD Disclosure. On July 27, 2026, the Company issued a press release announcing the Closing, and made available the Company’s investor presentation to be used in general corporate communications and investor communications. Copies of the press release and presentation are furnished as Exhibit 99.1 and Exhibit 99.2, respectively, to this Current Report on Form 8-K and incorporated herein by reference, except that the information contained on the websites referenced in the press release is not incorporated herein by reference. The information in this Item 7.01, including Exhibits 99.1 and 99.2, shall not be deemed “filed” for purposes of Section 18 of the Exchange Act, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act, or the Exchange Act, except as expressly set forth by specific reference in such filing.