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BCS

Changes in Beneficial Ownership · 4

OnKure Therapeutics, Inc.

OKURNASDAQEQUITYCurrent

Changes in Beneficial Ownership

Filed Aug 11, 2026Accepted Aug 11, 2026, 4:43 PM EDTFiling CIK 1637715Accession 0001193125-26-344874
Share

Structured filing — 4

ownership.xml

Open full document ↗

Filing details

Report period
2026-08-07
Issuer
OnKure Therapeutics, Inc.
Issuer CIK
0001637715
Trading symbol
OKUR

Reporting owner 1

Name
Mathers Edward T
Reporting owner CIK
0001328625
Relationship
Director
Address
104 5TH AVE, 19TH FLOOR, NEW YORK, NY, 10011

Derivative transactions

Derivative transactions · 1 reported row
SecurityConversion / exercise price (USD)Transaction dateCodeAmountA / DPrice (USD)ExercisableExpiresUnderlying securityUnderlying sharesOwned afterOwnership
Stock Option (right to buy)4.142026-08-07A · Form 422,350A0[F1]2036-08-06Class A Common Stock22,35022,350D
Table key
A · Form 4
Acquisition by grant, award or otherwise under Rule 16b-3(d)
A
Acquired
D
Direct

Footnotes

F1
100% of the shares subject to the option will vest on the earlier of June 4, 2027 or the day prior to the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person continuing as a service provider through the applicable vesting date.↩ 1

Signature 1

Signed
/s/ Zachary Bambach, attorney-in-fact
Date
2026-08-11

Company context

OnKure Therapeutics (Nasdaq: OKUR) is a clinical-stage biopharmaceutical company focused on the discovery and development of best-in-class precision medicines that target biologically validated drivers of vascular anomalies and cancers that are underserved by available therapies. Using a structure and computational chemistry-driven drug design platform, OnKure is committed to improving clinical outcomes for patients by building a pipeline of small molecule drugs designed to selectively target specific mutations thought to be key drivers of vascular anomalies and cancer. OnKure aims to become a leader in targeting PI3Kα and has multiple programs designed to enable best-in-class targeting of this important molecular target.

Current securities

Historical securities (1)

Recent company filings

  1. 4 filingSep 23, 2026
  2. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory ArrangementsAug 13, 2026
  3. 4 filingAug 11, 2026
  4. 424B5 filingAug 4, 2026
  5. Results of Operations and Financial ConditionAug 4, 2026

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