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BCS

Beneficial Ownership Report · SCHEDULE 13G

Replimune Group, Inc.

REPLNASDAQEQUITYCurrent

Beneficial Ownership Report

Filed Nov 10, 2026Accepted Nov 10, 2026, 9:10 AM ESTFiling CIK 1737953Accession 0000093751-26-000716
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Structured filing — SCHEDULE 13G

primary_doc.xml

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Subject company

Company
REPLIMUNE GROUP INC
Company CIK
0001737953
Street
500 UNICORN PARK DRIVE 3RD FLOOR
City
WOBURN
State / country code
MA
Postal code
01801

Statement details

Security class
COMMON STOCK
Event date
09/30/2026
Rule designation
Rule 13d-1(b)

Reporting person 1

Name
STATE STREET CORPORATION
Citizenship / organization
MA
Reporting person type
HC
Aggregate amount owned
4,174,260.00
Percent of class
4.4
Sole voting power
0.00
Shared voting power
4,080,714.00
Sole dispositive power
0.00
Shared dispositive power
4,174,260.00
Aggregate excludes certain shares
N

Item 1

Issuer

REPLIMUNE GROUP INC

Principal executive office address

500 UNICORN PARK DRIVE 3RD FLOOR, WOBURN, MASSACHUSETTS, 01801

Item 2

Citizenship

MA

Filing person

STATE STREET CORPORATION;

Principal business or residence address

ONE CONGRESS STREET, SUITE 1, BOSTON MA 02114, UNITED STATES

Item 3

Not applicable indication

N

Type of filing person

IA · HC

Item 4

Percent of class

4.4

Amount beneficially owned

4174260.00

Sole voting power

0

Shared voting power

4,080,714

Sole dispositive power

0

Shared dispositive power

4,174,260

Item 5

Not applicable indication

N

Ownership of 5% or less

Y

Item 6

Not applicable indication

N

Ownership on behalf of another person

NOT APPLICABLE

Item 7

Not applicable indication

N

Subsidiaries

SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA);STATE STREET GLOBAL ADVISORS TRUST COMPANY (IA);

Item 8

Not applicable indication

N

Group members

NOT APPLICABLE

Item 9

Not applicable indication

N

Item 10

Not applicable indication

N

Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Signature 1

Reporting person
STATE STREET CORPORATION
Signed
ALOK MAHESHWARY
Title
SENIOR VICE PRESIDENT
Date
11/09/2026

Company context

Replimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of novel oncolytic immunotherapies. Replimune’s proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is intended to ignite local activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to then activate a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit www.replimune.com.

Current securities

Recent company filings

  1. 4 filingNov 10, 2026
  2. 144 filingNov 9, 2026
  3. SCHEDULE 13G/A - filed by GOLDMAN SACHS GROUP INC regarding Replimune Group, Inc.Nov 9, 2026
  4. 10-Q/A filingNov 6, 2026
  5. 4 filingNov 3, 2026

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