Notice of Proposed Sale · 144

Spyre Therapeutics, Inc.

SYRENASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Oct 1, 2026Accepted Oct 1, 2026, 4:36 PM EDTFiling CIK 1758363Accession 0001950047-26-009978

View company →Permanent SEC source ↗

Structured filing — 144

primary_doc.xml

Open full document ↗

Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer: SPYRE THERAPEUTICS INC
Issuer CIK: 0001636282
SEC file number: 001-37722
Phone: 6176515940
Person for whose account securities are to be sold: CAMERON TURTLE
Relationships to issuer: Director · Officer
Street: 221 Crescent Street Building 23
City: Waltham
State / country code: MA
Postal code: 02453

Securities proposed for sale

Securities proposed for sale · 1 reported row
Security	Proposed units	Aggregate market value	Units outstanding	Approximate sale date	Exchange	Broker / market maker
Common	45,000	4,006,350.00	88,173,762	10/01/2026	NASDAQ	Morgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name: Morgan Stanley Smith Barney LLC Executive Financial Services
Street: 1 New York Plaza
Street (continued): 8th Floor
City: New York
State / country code: NY
Postal code: 10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
Security	Acquired	Nature of acquisition	Acquired from	Amount acquired	Gift transaction	Payment date	Nature of payment
Common	06/15/2023	Previously Exercised Stock Options	Issuer	45,000	N	06/15/2023	N/A

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
Seller	Security	Sale date	Amount sold	Gross proceeds
10b5-1 Sales for CAMERON W TURTLE	Common	09/01/2026	15,000	1,309,413.00
10b5-1 Sales for CAMERON W TURTLE	Common	08/03/2026	15,000	1,432,669.50

Seller — prior-sale row 1, entry 1

Name: 10b5-1 Sales for CAMERON W TURTLE
Street: 221 Crescent Street Building 23
City: Waltham
State / country code: MA
Postal code: 02453

Seller — prior-sale row 2, entry 1

Name: 10b5-1 Sales for CAMERON W TURTLE
Street: 221 Crescent Street Building 23
City: Waltham
State / country code: MA
Postal code: 02453

Prior-sale reporting

Nothing to report for the preceding three months: N

Notice signature

Notice date: 10/01/2026
Signed: /s/ Cameron Turtle
Plan adoption dates: 06/20/2025

Company context

Current securities

SYRENASDAQ · EQUITY · Current

Historical securities (1)

AGLEOTC · EQUITY · Historical · closed Nov 27, 2023

Free Registration