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BCS

Notice of Proposed Sale · 144

Septerna, Inc.

SEPNNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Aug 12, 2026Accepted Aug 12, 2026, 4:09 PM EDTFiling CIK 1778071Accession 0001974078-26-000301
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Septerna, Inc.
Issuer CIK
0001984086
SEC file number
001-42382
Phone
650-338-3533
Person for whose account securities are to be sold
Third Rock Ventures V, L.P.
Relationships to issuer
10% Stockholder
Street
250 EAST GRAND AVENUE, SUITE 65
City
SOUTH SAN FRANCISCO
State / country code
CA
Postal code
94080

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common147,2007,507,200.0046,676,94708/12/2026NasdaqRaymond James & Associates

Broker / market maker — proposed row 1, entry 1

Name
Raymond James & Associates
Street
880 Carillon Parkway
City
St. Petersburg
State / country code
FL
Postal code
33716

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common11/07/2022Original IssuanceSepterna, Inc.6,215,591N11/07/2022Cash

Prior-sale reporting

Nothing to report for the preceding three months
Y

Notice signature

Notice date
08/12/2026
Signed
Melissa Fisher, as duly authorized representative of Raymond James & Associates, Inc., as attorney-in-fact for Third Rock Ventures V, LP
Plan adoption dates
03/26/2026

Company context

Septerna, Inc. is a clinical-stage biotechnology company with a world-class team of GPCR experts and drug developers advancing cutting-edge science to unlock the full potential of GPCR therapies for patients with significant unmet needs. The company’s proprietary Native Complex Platform® is designed to enable new approaches to GPCR drug discovery and has led to the development of a diverse pipeline of novel oral small molecule drug candidates. Septerna is advancing programs in endocrinology, immunology and inflammation, metabolic diseases and additional therapeutic areas, both independently and with partners. For more information, please visit www.septerna.com.

Current securities

Recent company filings

  1. 4 filingOct 19, 2026
  2. 4 filingSep 10, 2026
  3. 3 filingSep 3, 2026
  4. Regulation FD Disclosure · Other EventsAug 25, 2026
  5. 4 filingAug 13, 2026

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