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BCS

Current Report · Items 8.01, 9.01 · 8-K

Aprea Therapeutics, Inc.

APRENASDAQEQUITYCurrent

Other Events

Item 8.01 Other Events. On August 28, 2026, Aprea Therapeutics, Inc. issued a press release announcing the expansion of the intellectual property portfolio for its precision oncology programs. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated by reference.

Filed Aug 28, 2026Accepted Aug 28, 2026, 8:30 AM EDTCIK 1781983Accession 0001104659-26-102795
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Company context

Aprea is a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers. The Company is pursuing an approach to treating cancer that seeks to exploit vulnerabilities associated with cancer cell mutations. This approach is designed to kill tumor cells while minimizing the effect on normal, healthy cells. Aprea believes its technology has potential applications across multiple cancer types, including ovarian, endometrial, colorectal and head and neck squamous cell carcinoma. The Company’s lead program is APR-1051, an oral, small molecule inhibitor of WEE1 kinase, currently in a Phase 1 clinical trial. The Company’s second clinical-stage product candidate, ATRN-119, is a small molecule ATR inhibitor for which the Company has completed a Phase 1/2a dose-escalation study and is exploring combination approaches. For more information, please visit the Company’s website at www.aprea.com.

Current securities

Recent company filings

  1. 10-Q filingNov 4, 2026
  2. Results of Operations and Financial Condition · Other EventsNov 4, 2026
  3. 10-Q filingAug 12, 2026
  4. Results of Operations and Financial Condition · Other EventsAug 12, 2026
  5. Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of ListingJul 23, 2026

Registered securities in this filing

Aprea Therapeutics, Inc. · 8-K · Filed 2026-08-28

As filed in this accession. Current/historical status below comes from the governed listing record; the cover itself remains exact to this filing.

Common stock, par value $0.001 per share

Symbol
APRE
Exchange
NASDAQ
Classification
COMMON
Status
Current
Filing context

Context: Duration_8_28_2026_To_8_28_2026_ELGFMuwTT0-axDPV4DYqYQ

Dimensions: Not supplied

Accession 000110465926102795 · 1 registered-security cover member

Read the exact SEC filing ↗

Disclosure sections

Items 8.01, 9.01

Select an item to read the extracted section. The as-filed document remains the primary evidence.

Item 8.01Item 8.01 - Other Events
Item 8.01 Other Events. On August 28, 2026, Aprea Therapeutics, Inc. issued a press release announcing the expansion of the intellectual property portfolio for its precision oncology programs. A copy of the press release is attached hereto as Exhibit 99.1 and incorporated by reference.
Filed exhibits (1)
EX-99.1 (by filename) apre-20260828xex99d1.htm

EX-99.1 2 apre-20260828xex99d1.htm EX-99.1 Exhibit 99.1 Aprea Therapeutics Announces Expansion of Intellectual Property Portfolio for Precision Oncology Programs Company Strengthens Global Intellectual Property Portfolio with 28 Issued and 30 Pending Patents DOYLESTOWN, PA, August 28, 2026 (GLOBE NEWSWIRE) - Aprea Therapeutics, Inc. (Nasdaq: APRE) (“Aprea”, or the “Company”), a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers, today provided an update on its existing patent portfolio. “Our expanding patent portfolio reflects Aprea’s commitment to innovation and building a differentiated leadership position in precision medicine,” said Oren Gilad, Ph. D., President and Chief Executive Officer of Aprea. “A strong global intellectual property portfolio is a critical component of our strategy, supporting the advancement of potentially best in class oncology therapies while protecting the long-term value of our programs. We remain focused on strengthening our intellectual property position as we advance our pipeline and pursue new treatment options for patients with diffi…

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