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BCS

Changes in Beneficial Ownership · 4

Taysha Gene Therapies, Inc.

TSHANASDAQEQUITYCurrent

Changes in Beneficial Ownership

Filed Jul 10, 2026Accepted Jul 10, 2026, 6:54 PM EDTFiling CIK 1806310Accession 0001665124-26-000013
Share

Structured filing — 4

form4-07102026_100732.xml

Open full document ↗

Filing details

Report period
2026-07-10
Issuer
Taysha Gene Therapies, Inc.
Issuer CIK
0001806310
Trading symbol
TSHA
Rule 10b5-1 indication
Checked

Reporting owner 1

Name
Nagendran Sukumar
Reporting owner CIK
0001665124
Relationship
Director · Officer
Officer title
President and Head of R&D
Address
C/O TAYSHA GENE THERAPIES, INC., 3000 PEGASUS PARK DRIVE, SUITE 1430, DALLAS, TX, 75247

Non-derivative transactions

Non-derivative transactions · 1 reported row
SecurityTransaction dateCodeAmountA / DPrice (USD)Owned afterOwnership
Common Stock2026-07-10S · Form 4[F1]200,000D6.24[F2]936,410D
Table key
S · Form 4
Sale on the market or privately
D
Direct

Footnotes

F1
This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 11, 2025.↩ 1
F2
The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.99 to $6.52 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.↩ 1

Signature 1

Signed
/s/ Kamran Alam, Attorney-in-Fact
Date
2026-07-10

Company context

Taysha Gene Therapies (Nasdaq: TSHA) is a clinical-stage biotechnology company focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system. Its lead clinical program TSHA-102 is in development for Rett syndrome, a rare neurodevelopmental disorder with no approved disease-modifying therapies that address the genetic root cause of the disease. With a singular focus on developing transformative medicines, Taysha aims to address severe unmet medical needs and dramatically improve the lives of patients and their caregivers. The Company’s management team has proven experience in gene therapy development and commercialization. Taysha leverages this experience, its manufacturing process and a clinically and commercially proven AAV9 capsid in an effort to rapidly translate treatments from bench to bedside. For more information, please visit www.tayshagtx.com.

Current securities

Recent company filings

  1. SCHEDULE 13G/A - filed by RA CAPITAL MANAGEMENT, L.P. regarding Taysha Gene Therapies, Inc.Aug 14, 2026
  2. SCHEDULE 13G/A - filed by MORGAN STANLEY regarding Taysha Gene Therapies, Inc.Aug 13, 2026
  3. 10-Q filingAug 11, 2026
  4. Results of Operations and Financial ConditionAug 11, 2026
  5. 144 filingJul 10, 2026

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