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Notice of Proposed Sale · 144

Orchestra BioMed Holdings, Inc.

OBIONASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Oct 1, 2026Accepted Oct 1, 2026, 10:37 AM EDTFiling CIK 1814114Accession 0001959173-26-007169
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Structured filing — 144

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Orchestra BioMed Holdings, Inc.
Issuer CIK
0001814114
SEC file number
001-39421
Phone
646-343-9298
Person for whose account securities are to be sold
Sherman Darren
Relationships to issuer
Officer · Director
Street
150 UNION SQUARE DRIVE
City
NEW HOPE
State / country code
PA
Postal code
18938

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common15,00094,050.0060,105,04910/01/2026NASDAQFidelity Brokerage Services LLC

Broker / market maker — proposed row 1, entry 1

Name
Fidelity Brokerage Services LLC
Street
900 Salem Street
City
Smithfield
State / country code
RI
Postal code
02917

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common11/25/2024Restricted Stock VestingIssuer15,000N11/25/2024Compensation

Sales reported in the preceding three months

Sales reported in the preceding three months · 3 reported rows
SellerSecuritySale dateAmount soldGross proceeds
Darren ShermanCommon07/01/202615,00064,066.02
Darren ShermanCommon08/03/202615,00061,291.68
Darren ShermanCommon09/01/202615,00074,059.38

Seller — prior-sale row 1, entry 1

Name
Darren Sherman
Street
150 Union Square Drive
City
New Hope
State / country code
PA
Postal code
18938

Seller — prior-sale row 2, entry 1

Name
Darren Sherman
Street
150 Union Square Drive
City
New Hope
State / country code
PA
Postal code
18938

Seller — prior-sale row 3, entry 1

Name
Darren Sherman
Street
150 Union Square Drive
City
New Hope
State / country code
PA
Postal code
18938

Prior-sale reporting

Nothing to report for the preceding three months
N

Notice signature

Notice date
10/01/2026
Signed
/s/ Margaret Campbell, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Darren Sherman
Plan adoption dates
12/18/2025

Company context

Orchestra BioMed is a biomedical innovation company accelerating high-impact technologies to patients through strategic collaborations with market-leading global medical device companies. The Company’s two flagship product candidates, Atrioventricular Interval Modulation (AVIM) Therapy and Virtue Sirolimus AngioInfusion Balloon (Virtue SAB), are currently undergoing pivotal clinical trials for their lead indications, each representing multi-billion-dollar annual global market opportunities. AVIM Therapy is a bioelectronic treatment for hypertension, the leading risk factor for death worldwide, and is designed to be delivered by a pacemaker and achieve immediate, substantial and sustained reductions in blood pressure in patients with hypertensive heart disease. The Company has a strategic collaboration with Medtronic, one of the largest medical device companies in the world and the global leader in cardiac pacing therapies, for the development and commercialization of AVIM Therapy for the treatment of uncontrolled hypertension in pacemaker-indicated patients. AVIM Therapy has FDA Breakthrough Device Designations for these patients, as well as an estimated 7.7 million total patients in the U.S. with uncontrolled hypertension despite medical therapy and increased cardiovascular risk. Virtue SAB is a highly differentiated, first-of-its-kind non-coated drug delivery angioplasty balloon system designed to deliver a large liquid dose of proprietary extended-release formulation of si

Current securities

Historical securities (1)

Recent company filings

  1. 4 filingOct 2, 2026
  2. Regulation FD Disclosure · Other EventsOct 1, 2026
  3. 4 filingSep 11, 2026
  4. Regulation FD DisclosureSep 8, 2026
  5. 4 filingSep 8, 2026

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