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BCS

Notice of Proposed Sale · 144

Tango Therapeutics, Inc.

TNGXNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Aug 3, 2026Accepted Aug 3, 2026, 4:47 PM EDTFiling CIK 1819133Accession 0001950047-26-007562
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
TANGO THERAPEUTICS, INC.
Issuer CIK
0001819133
SEC file number
001-39485
Phone
8573204900
Person for whose account securities are to be sold
ADAM CRYSTAL
Relationships to issuer
Officer
Street
201 BROOKLINE AVENUE, SUITE 901
City
BOSTON
State / country code
MA
Postal code
02215

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common81,0002,201,580.00144,647,98208/03/2026NASDAQMorgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name
Morgan Stanley Smith Barney LLC Executive Financial Services
Street
1 New York Plaza
Street (continued)
8th Floor
City
New York
State / country code
NY
Postal code
10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common08/03/2026Exercise of Stock OptionsIssuer81,000N08/03/2026Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
SellerSecuritySale dateAmount soldGross proceeds
10b5-1 Sales for ADAM CRYSTALCommon07/01/202627,000798,907.20
10b5-1 Sales for ADAM CRYSTALCommon06/01/202627,000617,571.00

Seller — prior-sale row 1, entry 1

Name
10b5-1 Sales for ADAM CRYSTAL
Street
201 BROOKLINE AVENUE, SUITE 901
City
BOSTON
State / country code
MA
Postal code
02215

Seller — prior-sale row 2, entry 1

Name
10b5-1 Sales for ADAM CRYSTAL
Street
201 BROOKLINE AVENUE, SUITE 901
City
BOSTON
State / country code
MA
Postal code
02215

Prior-sale reporting

Nothing to report for the preceding three months
N

Remarks

The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.

Notice signature

Notice date
08/03/2026
Signed
/s/ Adam Crystal
Plan adoption dates
10/27/2025

Company context

Tango Therapeutics is a clinical-stage biotechnology company dedicated to delivering breakthrough targeted therapies that extend and improve the lives of patients with cancer. Using an approach that focuses on genetic vulnerabilities in cancer, Tango is pursuing PRMT5-targeted therapies designed to address pancreatic and other forms of cancer while sparing healthy normal tissues.

Current securities

Historical securities (1)

Recent company filings

  1. Regulation FD Disclosure · Other EventsOct 23, 2026
  2. 144 filingSep 22, 2026
  3. 4 filingSep 3, 2026
  4. SCHEDULE 13G/A - filed by Nextech Crossover I GP S.a r.l. regarding Tango Therapeutics, Inc.Aug 14, 2026
  5. SCHEDULE 13G/A - filed by TCG Crossover GP II, LLC regarding Tango Therapeutics, Inc.Aug 14, 2026

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