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Notice of Proposed Sale · 144

Kymera Therapeutics, Inc.

KYMRNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Oct 1, 2026Accepted Oct 1, 2026, 4:10 PM EDTFiling CIK 1821189Accession 0001969223-26-001047
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Kymera Therapeutics, Inc.
Issuer CIK
0001815442
SEC file number
001-39460
Phone
857-285-5314
Person for whose account securities are to be sold
Mainolfi Nello
Relationships to issuer
Officer · Director
Street
500 NORTH BEACON STREET, 4TH FLOOR
City
WATERTOWN
State / country code
MA
Postal code
02472

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common30,0003,353,700.0083,150,61810/01/2026NASDAQUBS Financial Services, Inc.

Broker / market maker — proposed row 1, entry 1

Name
UBS Financial Services, Inc.
Street
11 Madison Ave
Street (continued)
4th Floor
City
New York
State / country code
NY
Postal code
10010

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common10/01/2026Exercise of stock optionsIssuer30,000N10/01/2026Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
SellerSecuritySale dateAmount soldGross proceeds
Nello MainolfiCommon07/01/202680,0009,223,529.00
Nello MainolfiCommon07/07/202650,0005,950,000.00

Seller — prior-sale row 1, entry 1

Name
Nello Mainolfi
Street
500 NORTH BEACON STREET
Street (continued)
4TH FLOOR
City
WATERTOWN
State / country code
MA
Postal code
02472

Seller — prior-sale row 2, entry 1

Name
Nello Mainolfi
Street
500 NORTH BEACON STREET
Street (continued)
4TH FLOOR
City
WATERTOWN
State / country code
MA
Postal code
02472

Prior-sale reporting

Nothing to report for the preceding three months
N

Notice signature

Notice date
10/01/2026
Signed
/s/ UBS Financial Services Inc, as attorney-in-fact for Nello Mainolfi
Plan adoption dates
03/24/2026

Company context

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X or LinkedIn.

Current securities

Recent company filings

  1. 4 filingSep 4, 2026
  2. 144 filingSep 4, 2026
  3. 144 filingSep 2, 2026
  4. SCHEDULE 13G/A - filed by Atlas Venture Fund X, L.P. regarding Kymera Therapeutics, Inc.Aug 13, 2026
  5. 10-Q filingAug 5, 2026

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