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Current Report · Items 8.01, 9.01 · 8-K

TransCode Therapeutics, Inc.

RNAZNASDAQEQUITYCurrent

Other Events

Item 8.01 Other Events. On September 28, 2026, TransCode Therapeutics, Inc. (“TransCode”) issued a press release announcing updated clinical data from its Phase 1a dose clinical trial of TTX-MC138. A copy of this press release is attached hereto as Exhibit 99.1 and incorporated herein by reference.

Filed Sep 28, 2026Accepted Sep 28, 2026, 8:16 AM EDTCIK 1829635Accession 0001104659-26-111170
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Company context

TransCode is a clinical-stage company pioneering immuno-oncology and RNA therapeutics for treatment of high risk and advanced cancers We possess a diversified pipeline of therapeutic candidates, including two clinical stage assets, TTX-MC138, an antisense inhibitor of an oncogenic microRNA and Seviprotimut-L, a cancer vaccine. We also possess an oncolytic immunotherapy platform and three TTX-based pre-clinical stage assets.

Current securities

Recent company filings

  1. 3 filingSep 21, 2026
  2. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory ArrangementsSep 11, 2026
  3. 10-Q filingAug 14, 2026
  4. Material Modification to Rights of Security Holders · Amendments to Articles of Incorporation or Bylaws; Change in Fiscal YearAug 3, 2026
  5. SCHEDULE 13G filingJul 28, 2026

Registered securities in this filing

TRANSCODE THERAPEUTICS, INC. · 8-K · Filed 2026-09-28

As filed in this accession. Current/historical status below comes from the governed listing record; the cover itself remains exact to this filing.

Common Stock, par value $0.0001 per share

Symbol
RNAZ
Exchange
NASDAQ
Classification
COMMON
Status
Current
Filing context

Context: AsOf2026-09-28

Dimensions: Not supplied

Accession 000110465926111170 · 1 registered-security cover member

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Disclosure sections

Items 8.01, 9.01

Select an item to read the extracted section. The as-filed document remains the primary evidence.

Item 8.01Item 8.01 - Other Events
Item 8.01 Other Events. On September 28, 2026, TransCode Therapeutics, Inc. (“TransCode”) issued a press release announcing updated clinical data from its Phase 1a dose clinical trial of TTX-MC138. A copy of this press release is attached hereto as Exhibit 99.1 and incorporated herein by reference.
Filed exhibits (1)
EX-99.1 (by filename) tm2626237d1_ex99-1.htm

Exhibit 99.1 TransCode Reports Continued Disease Stabilization and Extended Treatment Duration with TTX-MC138 in Ongoing Phase 1a Clinical Trial Follow-Up Updated clinical data reinforces evidence of antitumor activity in heavily pretreated patients with advanced solid tumors In the 14 efficacy-evaluable patients: o 71.4% stable disease rate o 57.1% of patients had disease control through three months of therapy o 36.7% maintained disease control through six months of therapy o Three efficacy-evaluable patients remain progression-free at one year Exploratory blood RNA-sequencing showed treatment-associated antitumor immune activation and biological features associated with stable disease. The primary endpoint of the study was met o No dose-limiting toxicities were reported across the evaluated dose levels BOSTON, MA, September 28, 2026 - TransCode Therapeutics, Inc. (NASDAQ: RNAZ), a clinical stage company pioneering immuno-oncology and RNA-based therapeutics for the treatment of high risk and advanced cancers, today announced updated clinical data from its Phase 1a clinical trial of TTX-MC138, its novel anti-miR-10b therap…

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