Notice of Proposed Sale · 144
Spyre Therapeutics, Inc.
SYRENASDAQEQUITYCurrent
Notice of Proposed Sale
Structured filing — 144
primary_doc.xml
Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.
Proposed-sale notice
- Issuer
- SPYRE THERAPEUTICS INC
- Issuer CIK
- 0001636282
- SEC file number
- 001-37722
- Phone
- 6176515940
- Person for whose account securities are to be sold
- SCOTT BURROWS
- Relationships to issuer
- Officer
- Street
- 221 Crescent Street Building 23
- City
- Waltham
- State / country code
- MA
- Postal code
- 02453
Securities proposed for sale
| Security | Proposed units | Aggregate market value | Units outstanding | Approximate sale date | Exchange | Broker / market maker |
|---|---|---|---|---|---|---|
| Common | 30,000 | 2,949,900.00 | 86,841,253 | 08/03/2026 | NASDAQ | Morgan Stanley Smith Barney LLC Executive Financial Services |
Broker / market maker — proposed row 1, entry 1
- Name
- Morgan Stanley Smith Barney LLC Executive Financial Services
- Street
- 1 New York Plaza
- Street (continued)
- 8th Floor
- City
- New York
- State / country code
- NY
- Postal code
- 10004
Acquisition of securities to be sold
| Security | Acquired | Nature of acquisition | Acquired from | Amount acquired | Gift transaction | Payment date | Nature of payment |
|---|---|---|---|---|---|---|---|
| Common | 08/03/2026 | Exercise of Stock Options | Issuer | 30,000 | N | 08/03/2026 | Cash |
Sales reported in the preceding three months
| Seller | Security | Sale date | Amount sold | Gross proceeds |
|---|---|---|---|---|
| 10b5-1 Sales for SCOTT BURROWS | Common | 07/01/2026 | 7,500 | 658,043.00 |
| SCOTT BURROWS | Common | 06/25/2026 | 15,000 | 1,307,000.00 |
| 10b5-1 Sales for SCOTT BURROWS | Common | 06/01/2026 | 7,500 | 532,948.25 |
Seller — prior-sale row 1, entry 1
- Name
- 10b5-1 Sales for SCOTT BURROWS
- Street
- 221 Crescent Street Building 23
- City
- Waltham
- State / country code
- MA
- Postal code
- 02453
Seller — prior-sale row 2, entry 1
- Name
- SCOTT BURROWS
- Street
- 221 Crescent Street Building 23
- City
- Waltham
- State / country code
- MA
- Postal code
- 02453
Seller — prior-sale row 3, entry 1
- Name
- 10b5-1 Sales for SCOTT BURROWS
- Street
- 221 Crescent Street Building 23
- City
- Waltham
- State / country code
- MA
- Postal code
- 02453
Prior-sale reporting
- Nothing to report for the preceding three months
- N
Remarks
The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
Notice signature
- Notice date
- 08/03/2026
- Signed
- /s/ Scott Burrows
- Plan adoption dates
- 11/10/2025
Company context
Spyre Therapeutics is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases. Spyre’s pipeline includes investigational extended half-life antibodies targeting α4ß7, TL1A, and IL-23.