Notice of Proposed Sale · 144

Spyre Therapeutics, Inc.

SYRENASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Sep 30, 2026Accepted Sep 30, 2026, 4:03 PM EDTFiling CIK 1853327Accession 0001950047-26-009876

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer: SPYRE THERAPEUTICS, INC.
Issuer CIK: 0001636282
SEC file number: 001-37722
Phone: (617) 651-5940
Person for whose account securities are to be sold: SCOTT BURROWS
Relationships to issuer: Officer
Street: 221 Crescent Street
Street (continued): Building 23, Suite 105
City: Waltham
State / country code: MA
Postal code: 02453

Securities proposed for sale

Securities proposed for sale · 1 reported row
Security	Proposed units	Aggregate market value	Units outstanding	Approximate sale date	Exchange	Broker / market maker
Common	17,500	1,573,157.25	88,173,762	09/30/2026	NASDAQ	Morgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name: Morgan Stanley Smith Barney LLC Executive Financial Services
Street: 1 New York Plaza
Street (continued): 8th Floor
City: New York
State / country code: NY
Postal code: 10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
Security	Acquired	Nature of acquisition	Acquired from	Amount acquired	Gift transaction	Payment date	Nature of payment
Common	09/30/2026	Stock Option Exercise	Issuer	17,500	N	09/30/2026	Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 4 reported rows
Seller	Security	Sale date	Amount sold	Gross proceeds
SCOTT BURROWS	Common	09/02/2026	18,232	1,629,029.20
SCOTT BURROWS	Common	09/01/2026	7,500	654,783.00
SCOTT BURROWS	Common	08/03/2026	7,500	716,761.00
SCOTT BURROWS	Common	07/01/2026	7,500	658,043.00

Seller — prior-sale row 1, entry 1

Name: SCOTT BURROWS
Street: 221 Crescent Street
Street (continued): Building 23, Suite 105
City: Waltham
State / country code: MA
Postal code: 02453

Seller — prior-sale row 2, entry 1

Name: SCOTT BURROWS
Street: 221 Crescent Street
Street (continued): Building 23, Suite 105
City: Waltham
State / country code: MA
Postal code: 02453

Seller — prior-sale row 3, entry 1

Name: SCOTT BURROWS
Street: 221 Crescent Street
Street (continued): Building 23, Suite 105
City: Waltham
State / country code: MA
Postal code: 02453

Seller — prior-sale row 4, entry 1

Name: SCOTT BURROWS
Street: 221 Crescent Street
Street (continued): Building 23, Suite 105
City: Waltham
State / country code: MA
Postal code: 02453

Prior-sale reporting

Nothing to report for the preceding three months: N

Notice signature

Notice date: 09/30/2026
Signed: /s/ Scott Burrows

Company context

Current securities

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Historical securities (1)

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