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Notice of Proposed Sale · 144

Mineralys Therapeutics, Inc.

MLYSNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Sep 30, 2026Accepted Sep 30, 2026, 4:07 PM EDTFiling CIK 1933414Accession 0001964306-26-000459
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Mineralys Therapeutics, Inc.
Issuer CIK
0001933414
SEC file number
001-41614
Phone
(888) 378-6240
Person for whose account securities are to be sold
Congleton Jon
Relationships to issuer
Officer · Director
Street
150 N. RADNOR CHESTER ROAD
Street (continued)
SUITE F200
City
RADNOR
State / country code
PA
Postal code
19087

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common Stock75,0001,909,661.6188,406,88509/30/2026NASDAQMerrill Lynch

Broker / market maker — proposed row 1, entry 1

Name
Merrill Lynch
Street
225 Liberty St
Street (continued)
37th Floor
City
New York
State / country code
NY
Postal code
10281

Acquisition of securities to be sold

Acquisition of securities to be sold · 5 reported rows
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common Stock01/10/2025Vesting of Restricted Stock Unit AwardsMineralys Therapeutics, Inc.3,194N01/10/2025Granted as part of issuer equity compensation plan
Common Stock04/10/2025Vesting of Restricted Stock Unit AwardsMineralys Therapeutics, Inc.20,635N04/10/2025Granted as part of issuer equity compensation plan
Common Stock07/10/2025Vesting of Restricted Stock Unit AwardsMineralys Therapeutics, Inc.20,070N07/10/2025Granted as part of issuer equity compensation plan
Common Stock10/10/2025Vesting of Restricted Stock Unit AwardsMineralys Therapeutics, Inc.20,854N10/10/2025Granted as part of issuer equity compensation plan
Common Stock01/10/2026Vesting of Restricted Stock Unit AwardsMineralys Therapeutics, Inc.10,247N01/10/2026Granted as part of issuer equity compensation plan

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
SellerSecuritySale dateAmount soldGross proceeds
Jon CongletonCommon Stock06/30/202675,0001,960,601.58
Jon CongletonCommon Stock07/13/202610,700291,441.17

Seller — prior-sale row 1, entry 1

Name
Jon Congleton
Street
150 N. RADNOR CHESTER RD
Street (continued)
SUITE F200
City
RADNOR
State / country code
PA
Postal code
19087

Seller — prior-sale row 2, entry 1

Name
Jon Congleton
Street
150 N. RADNOR CHESTER RD
Street (continued)
SUITE F200
City
RADNOR
State / country code
PA
Postal code
19087

Prior-sale reporting

Nothing to report for the preceding three months
N

Notice signature

Notice date
09/30/2026
Signed
Jon Congleton
Plan adoption dates
12/23/2025

Company context

Mineralys Therapeutics is a biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease, obstructive sleep apnea and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is an investigational, proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is based in Radnor, Pennsylvania, and was founded by Catalys Pacific. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, X and Bluesky.

Current securities

Recent company filings

  1. 4 filingOct 2, 2026
  2. 4 filingSep 22, 2026
  3. 4 filingSep 17, 2026
  4. 4 filingAug 25, 2026
  5. 4 filingAug 12, 2026

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