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Notice of Proposed Sale · 144

C4 Therapeutics, Inc.

CCCCNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Aug 14, 2026Accepted Aug 14, 2026, 7:14 PM EDTFiling CIK 1992219Accession 0001950047-26-008193

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Structured filing — 144

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer: C4 THERAPEUTICS, INC.
Issuer CIK: 0001662579
SEC file number: 001-39567
Phone: (617) 231-0700
Person for whose account securities are to be sold: Mark Mossler
Relationships to issuer: Officer
Street: 490 Arsenal Way,
Street (continued): Suite 120
City: Watertown
State / country code: MA
Postal code: 02472

Securities proposed for sale

Securities proposed for sale · 1 reported row
Security	Proposed units	Aggregate market value	Units outstanding	Approximate sale date	Exchange	Broker / market maker
Common	4,139	17,604.82	123,025,136	08/14/2026	NASDAQ	Morgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name: Morgan Stanley Smith Barney LLC Executive Financial Services
Street: 1 New York Plaza
Street (continued): 8th Floor
City: New York
State / country code: NY
Postal code: 10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 2 reported rows
Security	Acquired	Nature of acquisition	Acquired from	Amount acquired	Gift transaction	Payment date	Nature of payment
Common	02/14/2026	Restricted Stock	Issuer	1,152	N	02/14/2026	Not Applicable
Common	02/14/2025	Restricted Stock	Issuer	2,987	N	02/14/2025	Not Applicable

Sales reported in the preceding three months

Sales reported in the preceding three months · 3 reported rows
Seller	Security	Sale date	Amount sold	Gross proceeds
Mark Mossler	Common	08/13/2026	15,000	61,072.50
Mark Mossler	Common	08/12/2026	19,519	76,680.39
Mark Mossler	Common	05/27/2026	9,087	35,484.74

Seller — prior-sale row 1, entry 1

Name: Mark Mossler
Street: 490 Arsenal Way,
Street (continued): Suite 120
City: Watertown
State / country code: MA
Postal code: 02472

Seller — prior-sale row 2, entry 1

Name: Mark Mossler
Street: 490 Arsenal Way,
Street (continued): Suite 120
City: Watertown
State / country code: MA
Postal code: 02472

Seller — prior-sale row 3, entry 1

Name: Mark Mossler
Street: 490 Arsenal Way,
Street (continued): Suite 120
City: Watertown
State / country code: MA
Postal code: 02472

Prior-sale reporting

Nothing to report for the preceding three months: N

Notice signature

Notice date: 08/14/2026
Signed: /s/ Mark Mossler

Company context

Current securities

CCCCNASDAQ · EQUITY · Current

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