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Notice of Proposed Sale · 144

Rapport Therapeutics, Inc.

RAPPNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Sep 30, 2026Accepted Sep 30, 2026, 4:20 PM EDTFiling CIK 2012593Accession 0001950047-26-009884
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Rapport Therapeutics, Inc.
Issuer CIK
0002012593
SEC file number
001-42121
Phone
8573218020
Person for whose account securities are to be sold
CHERYL GAULT
Relationships to issuer
Officer
Street
99 High Street, Suite 2100
City
Boston
State / country code
MA
Postal code
02110

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common10,000330,200.0047,978,28609/30/2026NASDAQMorgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name
Morgan Stanley Smith Barney LLC Executive Financial Services
Street
1 New York Plaza
Street (continued)
8th Floor
City
New York
State / country code
NY
Postal code
10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common09/05/2024Founders SharesIssuer10,000N09/05/2024N/A

Prior-sale reporting

Nothing to report for the preceding three months
Y

Notice signature

Notice date
09/30/2026
Signed
/s/ Cheryl Gault
Plan adoption dates
12/10/2025

Company context

Rapport Therapeutics is a clinical-stage biotechnology company dedicated to discovering and developing small molecule precision medicines for patients with neurological and psychiatric disorders. The Company’s founders made pioneering discoveries related to the function of receptor associated proteins (RAPs) in the brain, which form the basis of Rapport’s RAP technology platform. The platform enables a differentiated approach to generate precision small molecule product candidates with the potential to overcome many limitations of conventional neurology drug discovery. Rapport’s precision neuroscience pipeline includes the Company’s lead investigational drug, RAP-219, which is designed to achieve neuroanatomical specificity through selective targeting of a RAP expressed only in discrete regions of the brain. The pipeline is anchored by the Company’s epilepsy portfolio, including FOS and primary generalized tonic-clonic seizures, as well as bipolar mania. The Company is also advancing additional discovery and preclinical programs leveraging its platform, including in chronic pain and migraine and in hearing and vestibular disorders. Availability of Other Information About Rapport Therapeutics Rapport Therapeutics uses and intends to continue to use its Investor Relations website and LinkedIn (Rapport Therapeutics) as a means of disclosing material nonpublic information and for complying with its disclosure obligations under Regulation FD. Accordingly, investors should monitor

Current securities

Recent company filings

  1. 4 filingOct 1, 2026
  2. 4 filingSep 24, 2026
  3. 4 filingSep 9, 2026
  4. 4 filingAug 26, 2026
  5. SCHEDULE 13G/A - filed by Third Rock Ventures V, L.P. regarding Rapport Therapeutics, Inc.Aug 14, 2026

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