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BCS

Notice of Proposed Sale · 144

Monte Rosa Therapeutics, Inc.

GLUENASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Jul 15, 2026Accepted Jul 15, 2026, 4:12 PM EDTFiling CIK 2025233Accession 0001969223-26-000786
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Monte Rosa Therapeutics, Inc.
Issuer CIK
0001826457
SEC file number
001-40522
Phone
617-949-2643
Person for whose account securities are to be sold
Champoux Jennifer
Relationships to issuer
Officer
Street
321 HARRISON AVENUE
Street (continued)
SUITE 900
City
BOSTON
State / country code
MA
Postal code
02118

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common4,351101,729.8684,479,41807/15/2026NASDAQUBS Financial Services, Inc.

Broker / market maker — proposed row 1, entry 1

Name
UBS Financial Services, Inc.
Street
11 Madison Ave
Street (continued)
4th Floor
City
New York
State / country code
NY
Postal code
10010

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common07/15/2026Exercise of stock optionsIssuer4,351N07/15/2026Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 4 reported rows
SellerSecuritySale dateAmount soldGross proceeds
Jennifer ChampouxCommon05/22/20262,17641,344.00
Jennifer ChampouxCommon05/27/20262,17543,500.00
Jennifer ChampouxCommon06/17/20262,17641,344.00
Jennifer ChampouxCommon06/23/20262,17543,500.00

Seller — prior-sale row 1, entry 1

Name
Jennifer Champoux
Street
321 HARRISON AVENUE
Street (continued)
SUITE 900
City
BOSTON
State / country code
MA
Postal code
02118

Seller — prior-sale row 2, entry 1

Name
Jennifer Champoux
Street
321 HARRISON AVENUE
Street (continued)
SUITE 900
City
BOSTON
State / country code
MA
Postal code
02118

Seller — prior-sale row 3, entry 1

Name
Jennifer Champoux
Street
321 HARRISON AVENUE
Street (continued)
SUITE 900
City
BOSTON
State / country code
MA
Postal code
02118

Seller — prior-sale row 4, entry 1

Name
Jennifer Champoux
Street
321 HARRISON AVENUE
Street (continued)
SUITE 900
City
BOSTON
State / country code
MA
Postal code
02118

Prior-sale reporting

Nothing to report for the preceding three months
N

Notice signature

Notice date
07/15/2026
Signed
/s/ UBS Financial Services Inc, as attorney-in-fact for Jennifer Champoux
Plan adoption dates
02/19/2026

Company context

Monte Rosa Therapeutics is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology, and proteomics to rationally design MGDs with unprecedented selectivity. Monte Rosa has developed the industry’s leading pipeline of first-in-class and only-in-class MGDs, spanning autoimmune and inflammatory diseases, oncology, and beyond, with three programs in the clinic. Monte Rosa has ongoing collaborations with leading pharmaceutical companies in the areas of immunology, oncology, and neurology. For more information, visit www.monterosatx.com.

Current securities

Recent company filings

  1. Regulation FD Disclosure · Other EventsOct 1, 2026
  2. Regulation FD Disclosure · Other EventsSep 8, 2026
  3. SCHEDULE 13G - filed by Vestal Point Capital, LP regarding Monte Rosa Therapeutics, Inc.Aug 14, 2026
  4. 10-Q filingAug 6, 2026
  5. Results of Operations and Financial ConditionAug 6, 2026

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