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BCS

Notice of Proposed Sale · 144

Septerna, Inc.

SEPNNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Oct 1, 2026Accepted Oct 1, 2026, 4:24 PM EDTFiling CIK 2040363Accession 0001950047-26-009949
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Septerna, Inc.
Issuer CIK
0001984086
SEC file number
001-42382
Phone
650-338-3533
Person for whose account securities are to be sold
SAMIRA SHAIKHLY
Relationships to issuer
Officer
Street
250 East Grand Avenue
City
South San Francisco
State / country code
CA
Postal code
94080

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common12,592492,724.9646,676,94710/01/2026NASDAQMorgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name
Morgan Stanley Smith Barney LLC Executive Financial Services
Street
1 New York Plaza
Street (continued)
8th Floor
City
New York
State / country code
NY
Postal code
10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common10/01/2026Exercise of Stock OptionsIssuer12,592N10/01/2026Cash

Prior-sale reporting

Nothing to report for the preceding three months
Y

Notice signature

Notice date
10/01/2026
Signed
/s/ Samira Shaikhly
Plan adoption dates
10/31/2025

Company context

Septerna, Inc. is a clinical-stage biotechnology company with a world-class team of GPCR experts and drug developers advancing cutting-edge science to unlock the full potential of GPCR therapies for patients with significant unmet needs. The company’s proprietary Native Complex Platform® is designed to enable new approaches to GPCR drug discovery and has led to the development of a diverse pipeline of novel oral small molecule drug candidates. Septerna is advancing programs in endocrinology, immunology and inflammation, metabolic diseases and additional therapeutic areas, both independently and with partners. For more information, please visit www.septerna.com.

Current securities

Recent company filings

  1. 4 filingSep 10, 2026
  2. 3 filingSep 3, 2026
  3. Regulation FD Disclosure · Other EventsAug 25, 2026
  4. 4 filingAug 13, 2026
  5. 10-Q filingAug 10, 2026

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