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Beneficial Ownership Report · SCHEDULE 13G

TScan Therapeutics, Inc.

TCRXNASDAQEQUITYCurrent

Beneficial Ownership Report

Filed Sep 25, 2026Accepted Sep 25, 2026, 4:12 PM EDTFiling CIK 2063423Accession 0002063423-26-000002
Share

Structured filing — SCHEDULE 13G

primary_doc.xml

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Subject company

Company
TScan Therapeutics, Inc.
Company CIK
0001783328
Street
830 Winter Street
City
Waltham
State / country code
MA
Postal code
02451

Statement details

Security class
Voting Common Stock, $0.0001 par value per share
Event date
09/21/2026
Rule designation
Rule 13d-1(c)

Reporting person 1

Name
Readout Capital, LP
Citizenship / organization
DE
Reporting person type
IA · PN
Aggregate amount owned
3,453,388.00
Percent of class
5.4
Sole voting power
0.00
Shared voting power
3,453,388.00
Sole dispositive power
0.00
Shared dispositive power
3,453,388.00

Reporting person 2

Name
Readout Capital GP, LLC
Citizenship / organization
DE
Reporting person type
HC
Aggregate amount owned
3,453,388.00
Percent of class
5.4
Sole voting power
0.00
Shared voting power
3,453,388.00
Sole dispositive power
0.00
Shared dispositive power
3,453,388.00

Reporting person 3

Name
Matthew Smith
Citizenship / organization
X1
Reporting person type
HC · IN
Aggregate amount owned
3,453,388.00
Percent of class
5.4
Sole voting power
0.00
Shared voting power
3,453,388.00
Sole dispositive power
0.00
Shared dispositive power
3,453,388.00

Item 1

Issuer

TScan Therapeutics, Inc.

Principal executive office address

830 Winter Street, Waltham, MASSACHUSETTS, 02451.

Item 2

Citizenship

See Item 4 of the cover page for each Reporting Person.

Filing person

This statement is being filed by (i) Readout Capital, LP, ( the "Firm"), (ii) Readout Capital GP, LLC ("Readout GP"), and (iii) Matthew Smith. Each a "Reporting Person." Readout GP is the General Partner to the Firm. Matthew Smit is a Managing Member of Readout GP.

Principal business or residence address

The principal business address of each of the Reporting Persons is 1630 Columbia Road NW, Unit 418, Washington, D.C. 20009.

Item 3

Not applicable indication

Y

Item 4

Percent of class

See Item 11 of the cover page for each Reporting Person.

Amount beneficially owned

See Item 9 of the cover page for each Reporting Person. By virtue of the Firm's position as the investment manager to Readout Capital Master Fund, LP (the "Master Fund") and the Sub-Advised Funds ("the Sub-Advised Funds"), the direct holders of an aggregate of 3,453,388 of Voting Common Stock, $0.0001 par value per share (the "Common Stock") of TScan Therapeutics, Inc. (the "Issuer"). The Firm may be deemed to exercise voting and investment power over such shares of Common Stock held by the Master Fund and the Sub-Advised Funds, and thus may be deemed to beneficially own such shares of Common Stock. By virtue of its position as the General Partner to the Firm, Readout GP may be deemed to exercise voting and investment power over the shares of Common Stock held directly by the Master Fund and the Sub-Advised Funds, and thus may be deemed to beneficially own such shares of Common Stock. By virtue of Matthew Smith's position as the Managing Member of Readout GP, Matthew Smith may be deemed to exercise voting and investment power over the shares of Common Stock held directly by the Master Fund and the Sub-Advised Funds, and thus may be deemed to beneficially own such shares of Common Stock. Ownership percentages are based on 63,502,667 shares of Common Stock reported as issued and outstanding as of August 7, 2026 in the Issuer's Quarterly Form 10-Q filed with the Securities and Exchange Commission on August 12, 2026.

Sole voting power

See Item 5 of the cover page for each Reporting Person.

Shared voting power

See Item 6 of the cover page for each Reporting Person.

Sole dispositive power

See Item 7 of the cover page for each Reporting Person.

Shared dispositive power

See Item 8 of the cover page for each Reporting Person.

Item 5

Not applicable indication

Y

Ownership of 5% or less

N

Item 6

Not applicable indication

Y

Item 7

Not applicable indication

Y

Item 8

Not applicable indication

Y

Item 9

Not applicable indication

Y

Item 10

Not applicable indication

N

Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Exhibits

Exhibit 1: Joint Filing Agreement

Signature 1

Reporting person
Readout Capital, LP
Signed
Scott Barnes
Title
Chief Compliance Officer
Date
09/25/2026

Signature 2

Reporting person
Readout Capital GP, LLC
Signed
Matthew Smith
Title
Managing Member
Date
09/25/2026

Signature 3

Reporting person
Matthew Smith
Signed
Matthew Smith
Title
Authorized Signatory
Date
09/25/2026

Filed exhibits

  • EX-1 ↗exhibit1jointfilingagreement.htm

Company context

TScan is a clinical-stage biotechnology company focused on the development of T cell receptor (TCR)-engineered T cell (TCR-T) therapies for the treatment of patients with cancer. The Company is advancing two therapeutics candidates through IND-enabling studies to treat solid tumors using in vivo-engineered TCR-T cells. In addition, the Company is seeking partnerships for its heme and autoimmune programs. To learn more, visit www.tscan.com and connect with us on LinkedIn and X.

Current securities

Recent company filings

  1. 4 filingOct 2, 2026
  2. 4 filingOct 2, 2026
  3. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory ArrangementsSep 30, 2026
  4. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory ArrangementsSep 11, 2026
  5. Costs Associated with Exit or Disposal Activities · Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing · Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements · Regulation FD Disclosure · Other EventsSep 2, 2026

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