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Notice of Proposed Sale · 144

Oruka Therapeutics, Inc.

ORKANASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Sep 21, 2026Accepted Sep 21, 2026, 4:27 PM EDTFiling CIK 907654Accession 0001950047-26-009701
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Oruka Therapeutics, Inc.
Issuer CIK
0000907654
SEC file number
000-22873
Phone
6506067910
Person for whose account securities are to be sold
Arjun Agarwal
Relationships to issuer
Officer
Street
855 Oak Grove Avenue Suite 100
City
Menlo Park
State / country code
CA
Postal code
94025

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common53350,613.6866,209,69909/21/2026NASDAQMorgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name
Morgan Stanley Smith Barney LLC Executive Financial Services
Street
1 New York Plaza
Street (continued)
8th Floor
City
New York
State / country code
NY
Postal code
10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common09/14/2026Restricted Stock UnitsIssuer533N09/14/2026N/A

Sales reported in the preceding three months

Sales reported in the preceding three months · 5 reported rows
SellerSecuritySale dateAmount soldGross proceeds
ARJUN AGARWALCommon09/15/202656053,597.60
10b5-1 Sales for ARJUN AGARWALCommon09/11/20269,459872,413.00
10b5-1 Sales for ARJUN AGARWALCommon08/13/202610,0001,066,571.87
10b5-1 Sales for ARJUN AGARWALCommon07/13/20269,999846,180.51
10b5-1 Sales for ARJUN AGARWALCommon06/22/20261,587128,468.24

Seller — prior-sale row 1, entry 1

Name
ARJUN AGARWAL
Street
855 Oak Grove Avenue Suite 100
City
Menlo Park
State / country code
CA
Postal code
94025

Seller — prior-sale row 2, entry 1

Name
10b5-1 Sales for ARJUN AGARWAL
Street
855 Oak Grove Avenue Suite 100
City
Menlo Park
State / country code
CA
Postal code
94025

Seller — prior-sale row 3, entry 1

Name
10b5-1 Sales for ARJUN AGARWAL
Street
855 Oak Grove Avenue Suite 100
City
Menlo Park
State / country code
CA
Postal code
94025

Seller — prior-sale row 4, entry 1

Name
10b5-1 Sales for ARJUN AGARWAL
Street
855 Oak Grove Avenue Suite 100
City
Menlo Park
State / country code
CA
Postal code
94025

Seller — prior-sale row 5, entry 1

Name
10b5-1 Sales for ARJUN AGARWAL
Street
855 Oak Grove Avenue Suite 100
City
Menlo Park
State / country code
CA
Postal code
94025

Prior-sale reporting

Nothing to report for the preceding three months
N

Notice signature

Notice date
09/21/2026
Signed
/s/ Arjun Agarwal
Plan adoption dates
02/11/2026

Company context

Oruka Therapeutics is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka’s mission is to offer patients suffering from inflammatory diseases like plaque psoriasis and hidradenitis suppurativa the greatest possible freedom from their condition by achieving high rates of disease clearance with dosing as infrequently as once or twice a year. For more information, visit www.orukatx.com and follow Oruka on LinkedIn.

Current securities

Recent company filings

  1. 144 filingSep 1, 2026
  2. 144 filingSep 1, 2026
  3. 424B5 filingAug 28, 2026
  4. EFFECT filingAug 27, 2026
  5. 4 filingAug 25, 2026

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