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BCS

Beneficial Ownership Report · SCHEDULE 13G/A

X4 Pharmaceuticals, Inc.

XFORNASDAQEQUITYCurrent

Beneficial Ownership Report

Filed Oct 7, 2026Accepted Oct 7, 2026, 11:47 AM EDTFiling CIK 1501697Accession 0000315066-26-002326
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Structured filing — SCHEDULE 13G/A

primary_doc.xml

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Amendment · This filing reports the amendment as submitted.

Subject company

Company
X4 PHARMACEUTICALS INC
Company CIK
0001501697
Street
61 NORTH BEACON STREET
Street (continued)
4TH FLOOR
City
BOSTON
State / country code
MA
Postal code
02134

Statement details

Amendment number
2
Security class
COMMON STOCK
Event date
09/30/2026
Rule designation
Rule 13d-1(b)

Reporting person 1

Name
FMR LLC
Citizenship / organization
DE
Reporting person type
HC
Aggregate amount owned
4,558,616.00
Percent of class
4.6
Sole voting power
4,558,586.00
Shared voting power
0.00
Sole dispositive power
4,558,616.00
Shared dispositive power
0.00

Reporting person 2

Name
Abigail P. Johnson
Citizenship / organization
X1
Reporting person type
IN
Aggregate amount owned
4,558,616.00
Percent of class
4.6
Sole voting power
0.00
Shared voting power
0.00
Sole dispositive power
4,558,616.00
Shared dispositive power
0.00

Item 1

Issuer

X4 PHARMACEUTICALS INC

Principal executive office address

61 NORTH BEACON STREET,4TH FLOOR,BOSTON,MA,US,02134

Item 2

Citizenship

Not applicable

Filing person

FMR LLC

Principal business or residence address

245 Summer Street, Boston, Massachusetts 02210

Item 3

Not applicable indication

N

Type of filing person

HC

Item 4

Percent of class

4.6

Amount beneficially owned

4558616.00

Sole voting power

Please see the responses to Items 5 and 6 on the cover page.

Shared voting power

0.00

Sole dispositive power

4558616.00

Shared dispositive power

0.00

Item 5

Not applicable indication

N

Ownership of 5% or less

Y

Item 6

Not applicable indication

N

Ownership on behalf of another person

One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of X4 PHARMACEUTICALS INC. No one other person's interest in the COMMON STOCK of X4 PHARMACEUTICALS INC is more than five percent of the total outstanding COMMON STOCK.

Item 7

Not applicable indication

N

Subsidiaries

See attached Exhibit 99.

Item 8

Not applicable indication

Y

Item 9

Not applicable indication

Y

Item 10

Not applicable indication

N

Certifications

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

Exhibits

Please see Exhibit 99 for 13d-1(k) (1) agreement.

Signature comments

* This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 10, 2023, accession number: 0000315066-23-000003. ** This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on January 31, 2023, accession number: 0000315066-23-000038.

Signature 1

Reporting person
FMR LLC
Signed
Stephanie J. Brown
Title
Duly authorized under Power of Attorney effective as of January 3, 2023, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date
10/06/2026

Signature 2

Reporting person
Abigail P. Johnson
Signed
Stephanie J. Brown
Title
Duly authorized under Power of Attorney effective as of January 26, 2023, by and on behalf of Abigail P. Johnson**
Date
10/06/2026

Filed exhibits

Company context

X4 is delivering progress for patients by developing and commercializing innovative therapies for those with rare hematology diseases and significant unmet needs. Leveraging expertise in CXCR4, X4 has successfully developed mavorixafor, an orally available CXCR4 antagonist that is currently being marketed in the U.S. as XOLREMDI® in its first indication. The company is also evaluating additional uses of mavorixafor and is conducting a global, pivotal Phase 3 clinical trial (4WARD) in people with certain

Current securities

Historical securities (2)

Recent company filings

  1. Entry into a Material Definitive Agreement · Termination of a Material Definitive Agreement · Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement · Unregistered Sales of Equity Securities · Regulation FD DisclosureOct 8, 2026
  2. 4 filingOct 5, 2026
  3. 144 filingOct 1, 2026
  4. Other EventsSep 9, 2026
  5. Other EventsSep 8, 2026

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