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Changes in Beneficial Ownership · 4

Revolution Medicines, Inc.

RVMDNASDAQEQUITYCurrent

Changes in Beneficial Ownership

Filed Sep 18, 2026Accepted Sep 18, 2026, 6:03 PM EDTFiling CIK 1628171Accession 0001294192-26-000007
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Structured filing — 4

ownership.xml

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Filing details

Report period
2026-09-16
Issuer
Revolution Medicines, Inc.
Issuer CIK
0001628171
Trading symbol
RVMD
Rule 10b5-1 indication
Checked

Reporting owner 1

Name
Horn Margaret A
Reporting owner CIK
0001294192
Relationship
Officer
Officer title
Chief Operating Officer
Address
REVOLUTION MEDICINES, INC., 700 SAGINAW DRIVE, REDWOOD CITY, CA, 94063

Non-derivative transactions

Non-derivative transactions · 2 reported rows
SecurityTransaction dateCodeAmountA / DPrice (USD)Owned afterOwnership
Common Stock2026-09-16S · Form 4[F1]76D195.0083[F2]154,571D
Common Stock2026-09-16S · Form 4[F1]4,891D199.3032149,680[F3]D
Table key
S · Form 4
Sale on the market or privately
D
Direct

Footnotes

F1
Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of restricted stock units.↩ 1↩ 2
F2
The transaction was executed in multiple trades at prices ranging from $195.00 to $195.03, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.↩ 1
F3
Includes 56,713 restricted stock units.↩ 1

Signature 1

Signed
/s/ Jack Anders, as Attorney-in-fact for Margaret A. Horn
Date
2026-09-18

Company context

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. These product candidates are investigational and have not been approved for commercial use in any indication. Additional development opportunities in the company’s pipeline focus on RAS(ON) mutant-selective inhibitors, including RMC-0708 (Q61H) and RMC-8839 (G13C). For more information, please visit www.revmed.com and follow us on LinkedIn.

Current securities

Recent company filings

  1. 144 filingSep 22, 2026
  2. 4 filingSep 18, 2026
  3. 4 filingSep 18, 2026
  4. 144 filingSep 18, 2026
  5. 144 filingSep 15, 2026

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