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Notice of Proposed Sale · 144

Revolution Medicines, Inc.

RVMDNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Sep 18, 2026Accepted Sep 18, 2026, 4:18 PM EDTFiling CIK 1628171Accession 0001950047-26-009664
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Structured filing — 144

primary_doc.xml

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer
Revolution Medicines, Inc.
Issuer CIK
0001628171
SEC file number
001-39219
Phone
6504816801
Person for whose account securities are to be sold
ANTHONY MANCINI
Relationships to issuer
Officer
Street
700 Saginaw Drive
City
Redwood City
State / country code
CA
Postal code
94063

Securities proposed for sale

Securities proposed for sale · 1 reported row
SecurityProposed unitsAggregate market valueUnits outstandingApproximate sale dateExchangeBroker / market maker
Common1,764347,402.16214,336,41809/18/2026NASDAQMorgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name
Morgan Stanley Smith Barney LLC Executive Financial Services
Street
1 New York Plaza
Street (continued)
8th Floor
City
New York
State / country code
NY
Postal code
10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 1 reported row
SecurityAcquiredNature of acquisitionAcquired fromAmount acquiredGift transactionPayment dateNature of payment
Common09/15/2026Restricted Stock UnitsIssuer1,764N09/15/2026N/A

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
SellerSecuritySale dateAmount soldGross proceeds
ANTHONY MANCINICommon09/15/20261,774353,449.03
10b5-1 Sales for ANTHONY MANCINICommon09/10/202615,4483,153,807.11

Seller — prior-sale row 1, entry 1

Name
ANTHONY MANCINI
Street
700 Saginaw Drive
City
Redwood City
State / country code
CA
Postal code
94063

Seller — prior-sale row 2, entry 1

Name
10b5-1 Sales for ANTHONY MANCINI
Street
700 Saginaw Drive
City
Redwood City
State / country code
CA
Postal code
94063

Prior-sale reporting

Nothing to report for the preceding three months
N

Notice signature

Notice date
09/18/2026
Signed
/s/ Anthony Mancini
Plan adoption dates
06/11/2026

Company context

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. These product candidates are investigational and have not been approved for commercial use in any indication. Additional development opportunities in the company’s pipeline focus on RAS(ON) mutant-selective inhibitors, including RMC-0708 (Q61H) and RMC-8839 (G13C). For more information, please visit www.revmed.com and follow us on LinkedIn.

Current securities

Recent company filings

  1. 144 filingSep 22, 2026
  2. 4 filingSep 18, 2026
  3. 4 filingSep 18, 2026
  4. 4 filingSep 18, 2026
  5. 144 filingSep 15, 2026

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