Notice of Proposed Sale · 144

Xeris Biopharma Holdings, Inc.

XERSNASDAQEQUITYCurrent

Notice of Proposed Sale

Filed Jul 1, 2026Accepted Jul 1, 2026, 4:51 PM EDTFiling CIK 1652410Accession 0001950047-26-006741

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Structured filing — 144

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Notice of proposed sale. The proposed amounts below do not establish that a sale occurred.

Proposed-sale notice

Issuer: XERIS BIOPHARMA HOLDINGS, INC.
Issuer CIK: 0001867096
SEC file number: 001-40880
Phone: 8444455704
Person for whose account securities are to be sold: BETH HECHT
Relationships to issuer: Officer
Street: 1375 West Fulton Street, Suite 1300
City: Chicago
State / country code: IL
Postal code: 60607

Securities proposed for sale

Securities proposed for sale · 1 reported row
Security	Proposed units	Aggregate market value	Units outstanding	Approximate sale date	Exchange	Broker / market maker
Common	49,998	395,984.16	172,642,055	07/01/2026	NASDAQ	Morgan Stanley Smith Barney LLC Executive Financial Services

Broker / market maker — proposed row 1, entry 1

Name: Morgan Stanley Smith Barney LLC Executive Financial Services
Street: 1 New York Plaza
Street (continued): 8th Floor
City: New York
State / country code: NY
Postal code: 10004

Acquisition of securities to be sold

Acquisition of securities to be sold · 3 reported rows
Security	Acquired	Nature of acquisition	Acquired from	Amount acquired	Gift transaction	Payment date	Nature of payment
Common	01/31/2023	Restricted Stock Units	Issuer	37,409	N	01/31/2023	N/A
Common	06/30/2020	Employee Stock Purchase Plan	Issuer	10,026	N	06/30/2020	Cash
Common	03/13/2020	Open Market Purchase	Issuer	2,563	N	03/13/2020	Cash

Sales reported in the preceding three months

Sales reported in the preceding three months · 2 reported rows
Seller	Security	Sale date	Amount sold	Gross proceeds
10b5-1 Sales for BETH HECHT	Common	06/01/2026	16,667	100,982.35
10b5-1 Sales for BETH HECHT	Common	05/01/2026	16,667	103,805.37

Seller — prior-sale row 1, entry 1

Name: 10b5-1 Sales for BETH HECHT
Street: 1375 West Fulton Street, Suite 1300
City: Chicago
State / country code: IL
Postal code: 60607

Seller — prior-sale row 2, entry 1

Name: 10b5-1 Sales for BETH HECHT
Street: 1375 West Fulton Street, Suite 1300
City: Chicago
State / country code: IL
Postal code: 60607

Prior-sale reporting

Nothing to report for the preceding three months: N

Remarks

The 10,026 securities to be sold were acquired upon the acquisition of employee stock purchase plan shares during the period of 06/30/2020 through 06/30/2024.

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